Analysis of antibody and Fc-fusion protein INNs
With our general interest in antibody engineering and particularly Fc silencing we set out to analyse the Fc mutations that have been utilised in the clinic. Our efforts to obtain this information from other publicly available resources turned out to be fruitless and so instead we systematically cataloged, verified, analysed and annotated all antibody and Fc fusion proteins that have a registered international non-proprietary name (INN) with the World Health Organisation (WHO). We have amassed sequence information for over 800 antibody-based biologics and provide information on the primary amino acid sequence, design format, isotype, subtype, allotype and mutations. The searchable table below provides an overview of this information. Much more detailed information can be obtained from our publication and accompanying downloadable spreadsheet which can be accessed from the mAbs journal by clicking the image to the right.
INN | Format | Antigen | Effector function | Half-life | Heterodimerization | Site specific conj | Stabilized | C-term truncation | Other |
---|---|---|---|---|---|---|---|---|---|
abagovomab | IgG | idiotype of anti-CA125 | |||||||
abatacept | Fc fusion protein (type 1) | CD80/CD86 | |||||||
abciximab | Unconfirmed | GPIIB/IIIA | |||||||
abelacimab | IgG | Factor XI | ↓ | ||||||
abituzumab | IgG | Integrin alpha5 | ↓ | ||||||
abrezekimab | Fab | IL-13 | |||||||
abrilumab | IgG | Integrin alpha4/beta7 | |||||||
acapatamab | Tandem scFv-scFc | PSMA | ↓ | Yes | |||||
acasunlimab | Bispecific IgG (type 6) | PD-L1 | ↓ | Yes | Yes | ||||
acazicolcept | Fc fusion protein (type 1) | CD278/CD28 | ↓ | Yes | |||||
acrixolimab | IgG | PD-1 | Yes | ||||||
actoxumab | IgG | Clostridium difficile enterotoxin B | |||||||
adalimumab | Unconfirmed | TNF alpha | |||||||
adebrelimab | IgG | PD-L1 | ↓ | Yes | |||||
adecatumumab | IgG | EpCAM | |||||||
adintrevimab | IgG | SARS-CoV-2 | ↑ | ||||||
aducanumab | IgG | Amyloid beta | Yes | ||||||
afasevikumab | IgG | IL-17 | |||||||
afelimomab | Unconfirmed | TNF alpha | |||||||
aflibercept | Fc fusion protein (type 1) | VEGF | Yes | Yes | |||||
alacizumab | di-Fab' | VEGF-R2 | |||||||
alefacept | Fc fusion protein (type 1) | CD2 | |||||||
alemtuzumab | IgG | CD52 | |||||||
alirocumab | IgG | PCSK9 | Yes | ||||||
alnuctamab | Fab-IgG (type 1) | BCMA | ↓ | Yes | Yes | ||||
alomfilimab | IgG | CD278 | |||||||
alsevalimab | IgG | B7-H4 | ↑ | ||||||
altumomab | Unconfirmed | CEACAM5 | |||||||
amatuximab | IgG | Mesothelin | |||||||
amivantamab | Bispecific IgG (type 6) | EGFR | Yes | ||||||
amlitelimab | IgG | OX40L | ↓ | Yes | |||||
amubarvimab | IgG | SARS-CoV-2 | ↑ | ||||||
anatumomab | Unconfirmed | GP72 | |||||||
anbenitamab | Bispecific IgG (type 2) | HER2 | Yes | ||||||
andecaliximab | IgG | MMP9 | Yes | ||||||
anetumab | IgG | Mesothelin | Yes | ||||||
anifrolumab | IgG | Interferon receptor | ↓ | ||||||
anivovetmab | IgG | VP2 (canine) | |||||||
anrukinzumab | IgG | IL-13 | ↓ | ||||||
anselamimab | IgG | Amyloid | |||||||
ansuvimab | IgG | Ebola virus | |||||||
anumigilimab | IgG | CD114 | Yes | ||||||
apamistamab | IgG | CD45 | |||||||
apitegromab | IgG | Myostatin | Yes | Yes | |||||
apolizumab | Unconfirmed | HLA-DR | |||||||
aprutumab | IgG | FGFR2 | Yes | ||||||
arcitumomab | IgG | CEACAM5 | |||||||
ascrinvacumab | IgG | ALK1 | |||||||
aselizumab | IgG | CD62L | |||||||
asfotase | Fc fusion protein (type 1) | hypophosphatasia | |||||||
astegolimab | IgG | IL-33R | |||||||
asunercept | Fc fusion protein (type 1) | CD95L | |||||||
atacicept | Fc fusion protein (type 1) | BLyS/APRIL | ↓ | ||||||
atezolizumab | IgG | PD-L1 | ↓ | ||||||
atibuclimab | IgG | CD14 | |||||||
atidortoxumab | IgG | Staphylococcus aureus | Yes | ||||||
atinumab | IgG | NOGO-A | |||||||
atoltivimab | IgG | Ebola virus | |||||||
atorolimumab | Unconfirmed | Rhesus D | |||||||
avdoralimab | IgG | C5aR | ↓ | ||||||
avelumab | IgG | PD-L1 | |||||||
avizakimab | IgG | IL-21 | ↑ | ||||||
axatilimab | IgG | CD115 | Yes | ||||||
azintuxizumab | IgG | SLAMF7 | |||||||
bafisontamab | Fab-IgG (type 2) | EGFR | |||||||
balstilimab | IgG | PD-1 | Yes | ||||||
baminercept | Fc fusion protein (type 1) | Lymphotoxin beta | Yes | ||||||
bamlanivimab | IgG | SARS-CoV-2 | |||||||
bapineuzumab | IgG | Amyloid beta | Yes | ||||||
bapotulimab | IgG | ILDR2 | Yes | ||||||
barecetamab | IgG | HER3 | Yes | ||||||
barzolvolimab | IgG | CD117 | ↓ | ↑ | Yes | ||||
basiliximab | Unconfirmed | CD25 | |||||||
batiraxcept | Fc fusion protein (type 1) | GAS6 | Yes | ||||||
batoclimab | IgG | FcRn | ↓ | Yes | |||||
bavituximab | IgG | Phosphatidylserine | Yes | ||||||
bavunalimab | Heterodimeric Fab/scFv-Fc | CTLA-4 | ↓ | ↑ | Yes | ||||
bebtelovimab | IgG | SARS-CoV-2 | |||||||
bectumomab | Unconfirmed | CD22 | |||||||
bedinvetmab | IgG | NGF (canine) | ↓ | ||||||
befovacimab | IgG | Tissue factor pathway inhibitor | Yes | ||||||
begelomab | IgG | DPP4 | |||||||
belantamab | IgG | BCMA | ↑ | ||||||
belatacept | Fc fusion protein (type 1) | CD80/CD86 | |||||||
belimumab | IgG | BLys | |||||||
beludavimab | IgG | SARS-CoV-2 | ↑ | ↑ | |||||
bemarituzumab | IgG | FGFR2 | ↑ | ||||||
benralizumab | IgG | IL-5 | |||||||
bentracimab | Fab | IL-5R | |||||||
benufutamab | IgG | DR5 | ↑ | Yes | |||||
bepranemab | IgG | Tau | Yes | ||||||
berlimatoxumab | IgG | Staphylococcus aureus | Yes | ||||||
bermekimab | IgG | IL-1 alpha | |||||||
bersanlimab | IgG | CD54 | |||||||
bertilimumab | Unconfirmed | Eotaxin-1 | |||||||
besilesomab | Unconfirmed | NCA-95 | |||||||
betifisolimab | IgG | PD-L1 | ↓ | ||||||
bevacizumab | IgG | VEGF | |||||||
bexmarilimab | IgG | Clever-1 | ↓ | Yes | |||||
bezlotoxumab | IgG | Clostridium difficile enterotoxin B | |||||||
biciromab | Unconfirmed | Fibrin | |||||||
bifikafusp | scFv-protein fusion | Fibronectin | |||||||
bimagrumab | IgG | ActRIIA ligands | ↓ | ||||||
bimekizumab | IgG | IL-17A/IL-17F | |||||||
bintrafusp | IgG-protein fusion (type 1) | PD-L1 | Yes | ||||||
birtamimab | IgG | Amyloid | |||||||
bivatuzumab | Unconfirmed | CD44v6 | |||||||
bleselumab | IgG | CD40 | ↓ | Yes | |||||
blinatumomab | Tandem scFv | CD19 | |||||||
blisibimod | Fc fusion protein (type 1) | BAFF | |||||||
blontuvetmab | IgG | MS4A1 | |||||||
blosozumab | IgG | Sclerostin | Yes | Yes | |||||
bococizumab | IgG | PCSK9 | ↓ | ||||||
botensilimab | IgG | CTLA-4 | ↑ | Yes | |||||
brazikumab | IgG | IL-23 | |||||||
brentuximab | IgG | CD30 | Yes | ||||||
briakinumab | IgG | IL-12 beta | |||||||
briobacept | Fc fusion protein (type 1) | BLys | Yes | ||||||
briquilimab | IgG | CD117 | ↓ | ||||||
brodalumab | IgG | IL-17RA | |||||||
brolucizumab | scFv | VEGF | |||||||
brontictuzumab | IgG | Notch-1 | |||||||
budigalimab | IgG | PD-1 | ↓ | ||||||
burfiralimab | IgG | Vimentin | |||||||
burosumab | IgG | FGF23 | |||||||
cabiralizumab | IgG | CD115 | Yes | ||||||
cadonilimab | IgG-scFv (type 1) | PD-1 | ↓ | ||||||
camidanlumab | IgG | CD25 | |||||||
camoteskimab | IgG | IL-18 | ↓ | ||||||
camrelizumab | IgG | PD-1 | Yes | ||||||
canakinumab | IgG | IL-1 beta | |||||||
cantuzumab | IgG | MUC1 | |||||||
caplacizumab | Tandem dAb (type 1) | von Willebrand factor | |||||||
capromab | Unconfirmed | PSMA | |||||||
carlumab | IgG | CCL2 | |||||||
carotuximab | IgG | Endoglin | |||||||
casirivimab | IgG | SARS-CoV-2 | |||||||
catumaxomab | Unconfirmed | EpCAM | |||||||
cedelizumab | Unconfirmed | CD4 | |||||||
cemiplimab | IgG | PD-1 | Yes | ||||||
cendakimab | IgG | IL-13 | ↓ | ||||||
cergutuzumab | IgG-protein fusion (type 2) | CEACAM5 | ↓ | Yes | Yes | ||||
certolizumab | Fab | TNF alpha | |||||||
cetrelimab | IgG | PD-1 | Yes | ||||||
cetuximab | IgG | EGFR | |||||||
cevostamab | Bispecific IgG (type 1) | FcRL5 | ↓ | Yes | |||||
cibisatamab | Fab-IgG (type 1) | CEACAM5 | ↓ | Yes | |||||
cifurtilimab | IgG | CD40 | |||||||
cilgavimab | IgG | SARS-CoV-2 | ↓ | ↑ | |||||
cinpanemab | IgG | Synuclein alpha | Yes | ||||||
cinrebafusp | IgG-protein fusion (type 1) | HER2 | ↓ | Yes | |||||
cirevetmab | IgG | TGF beta (canine) | ↓ | ||||||
citatuzumab | Fab-protein fusion (type 2) | EpCAM | |||||||
cixutumumab | IgG | IGF1R | |||||||
clazakizumab | IgG | IL-6 | ↓ | ||||||
clenoliximab | Unconfirmed | CD4 | |||||||
clervonafusp | Fab-protein fusion (type 1) | SLC29A2 | |||||||
clesrovimab | IgG | Respiratory syncytial virus | ↑ | ||||||
clivatuzumab | IgG | MUC1 | |||||||
cobolimab | IgG | TIM-3 | Yes | ||||||
codrituzumab | IgG | GPC3 | |||||||
cofetuzumab | IgG | PTK7 | Yes | ||||||
coltuximab | IgG | CD19 | |||||||
conatumumab | IgG | TRAIL-R2 | |||||||
conbercept | Fc fusion protein (type 1) | VEGF | ↑ | ||||||
concizumab | IgG | Tissue factor pathway inhibitor | Yes | ||||||
coprelotamab | IgG | HER2 | |||||||
cosfroviximab | IgG | Ebola virus | |||||||
cosibelimab | IgG | PD-L1 | |||||||
crefmirlimab | Minibody | CD8A | Yes | ||||||
crenezumab | IgG | Amyloid beta | Yes | Yes | |||||
crexavibart | IgG | SARS-CoV-2 | ↑ | Yes | |||||
crizanlizumab | IgG | CD62 | ↓ | ||||||
crotedumab | IgG | GCGR | Yes | ||||||
crovalimab | IgG | C5 | ↓ | ↑ | Yes | Yes | |||
cudarolimab | IgG | OX40 | Yes | ||||||
cusatuzumab | IgG | CD70 | ↑ | ||||||
dacetuzumab | IgG | CD40 | |||||||
daclizumab | IgG | CD25 | |||||||
dafsolimab | IgG | CD3 | |||||||
dalantercept | Fc fusion protein (type 1) | BMP9/BMP10 | ↓ | Yes | |||||
dalotuzumab | IgG | IGF1R | |||||||
dalutrafusp | IgG-protein fusion (type 1) | CD73 | ↓ | Yes | |||||
dapirolizumab | Fab | CD40L | |||||||
daratumumab | IgG | CD38 | |||||||
datopotamab | IgG | TROP-2 | |||||||
davoceticept | Fc fusion protein (type 1) | CD28/PD-L1/CTLA-4 | ↓ | Yes | |||||
daxdilimab | IgG | ILT7 | ↑ | ||||||
dectrekumab | IgG | IL-13 | |||||||
demcizumab | IgG | DLL4 | Yes | ||||||
demupitamab | IgG | EGFR | |||||||
denintuzumab | IgG | CD19 | |||||||
denosumab | IgG | RANKL | |||||||
depatuxizumab | IgG | EGFR | |||||||
depemokimab | IgG | IL-5 | ↑ | ||||||
derlotuximab | IgG | DNA-associated antigens | ↑ | ||||||
detumomab | Unconfirmed | B-lymphoma cell | |||||||
dezamizumab | IgG | Serum amyloid P component | |||||||
dilpacimab | Fv-IgG | DLL4 | ↓ | ||||||
dinutuximab | IgG | GD2 | |||||||
diridavumab | IgG | Influenza A hemagglutinin | Yes | ||||||
disitamab | IgG | HER2 | |||||||
divozilimab | IgG | CD20 | |||||||
docaravimab | IgG | Rabies virus | |||||||
domagrozumab | IgG | Myostatin | ↓ | ||||||
domvanalimab | IgG | TIGIT | ↓ | Yes | |||||
donanemab | IgG | Amyloid beta | Yes | ||||||
dorlimomab | Unconfirmed | ricin | |||||||
dostarlimab | IgG | PD-1 | Yes | ||||||
dovanvetmab | IgG | IL-31 (feline) | ↓ | ||||||
dresbuxelimab | IgG | CD73 | ↓ | ||||||
drozitumab | IgG | DR5 | Yes | ||||||
dulaglutide | Fc fusion protein (type 1) | GLP-1R | ↓ | Yes | |||||
duligotuzumab | IgG | HER3 | |||||||
dupilumab | IgG | IL-4R | Yes | Yes | |||||
durvalumab | IgG | PD-L1 | ↓ | ||||||
dusigitumab | IgG | IGF1/IGF2 | |||||||
duvortuxizumab | Diabody-Fc (type 2) | CD19 | ↓ | Yes | Yes | ||||
ebdarokimab | IgG | IL-12 beta | |||||||
eblasakimab | IgG | IL-13R alpha1 | Yes | ||||||
ebronucimab | IgG | PCSK9 | |||||||
ecleralimab | Fab | Thymic stromal lymphopoietin | |||||||
ecromeximab | IgG | GD3 | |||||||
eculizumab | IgG | C5 | |||||||
edobacomab | Unconfirmed | Endotoxin | |||||||
edrecolomab | Unconfirmed | EpCAM | |||||||
efalizumab | IgG | CD11a | |||||||
efanesoctocog | Fc fusion protein (type 7) | Hemophilia | Yes | ||||||
efaprinermin | Fc fusion protein (type 1) | GITR | Yes | ||||||
efavaleukin | Fc fusion protein (type 6) | IL-2R | ↓ | Yes | |||||
efbemalenograstim | Fc fusion protein (type 1) | CD114 | ↓ | ||||||
efdamrofusp | Fc fusion protein (type 3) | VEGF | |||||||
efepoetin | Fc fusion protein (type 1) | EpoR | |||||||
efgartigimod | Fc domain | FcRn | Yes | ||||||
efgivanermin | Fc fusion protein (type 6) | GITR | |||||||
efineptakin | Fc fusion protein (type 1) | IL-7R | |||||||
efinopegdutide | Protein conjugated Fc | GLP-1R | |||||||
efizonerimod | Fc fusion protein (type 6) | TNFR | |||||||
eflapegrastim | Protein conjugated Fc | GCSFR | |||||||
eflenograstim | Fc fusion protein (type 1) | GCSFR | |||||||
eflepedocokin | Fc fusion protein (type 1) | IL-22R | ↓ | ||||||
eflimrufusp | Fc fusion protein (type 1) | VEGF | |||||||
efmarodocokin | Fc fusion protein (type 1) | IL-22R | ↓ | ||||||
efmitermant | Fc fusion protein (type 1) | Myostatin | |||||||
efmoroctocog | Fc fusion protein (type 5) | Hemophilia | Yes | ||||||
efocipegtrutide | Protein conjugated Fc | glucagon/GLP1/GIP | |||||||
efpeglenatide | Small molecule conjugated Fc | GLP-1R | |||||||
efpegsomatropin | Protein conjugated Fc | HGHR | |||||||
efprezimod | Fc fusion protein (type 1) | unknown | |||||||
efrilacedase | Fc fusion protein (type 1) | Angiotensin | |||||||
efruxifermin | Fc fusion protein (type 6) | FGFR | |||||||
eftansomatropin | Fc fusion protein (type 1) | HGHR | |||||||
eftilagimod | Fc fusion protein (type 1) | HLA-DR | |||||||
eftozanermin | Fc fusion protein (type 1) | DR4/DR5 | ↓ | ||||||
eftrenonacog | Fc fusion protein (type 5) | Hemophilia | Yes | ||||||
efungumab | scFv | HSP90 | |||||||
efzofitimod | Fc fusion protein (type 6) | Neuropilin-2 | |||||||
eldelumab | IgG | CXCL10 | |||||||
elezanumab | IgG | Repulsive Guidance Molecule A | ↓ | ↑ | |||||
elgemtumab | IgG | HER3 | |||||||
elipovimab | IgG | HIV gp120 | ↑ | ↑ | |||||
elotuzumab | IgG | SLAMF7 | |||||||
elranatamab | Bispecific IgG (type 6) | BCMA | ↓ | Yes | |||||
elsilimomab | Unconfirmed | IL-6 | |||||||
eluvixtamab | Tandem scFv | CD33 | |||||||
emactuzumab | IgG | CD115 | |||||||
emapalumab | IgG | Interferon gamma | |||||||
emerfetamab | Tandem scFv-scFc | CD33 | ↓ | Yes | |||||
emfizatamab | IgG-scFv (type 2) | CD19 | ↓ | Yes | |||||
emibetuzumab | IgG | HGFR | ↓ | Yes | Yes | ||||
emicizumab | Bispecific IgG (type 2) | Factor Ixa | Yes | Yes | Yes | ||||
emirodatamab | Tandem scFv-scFc | FLT3 | ↓ | Yes | |||||
enapotamab | IgG | AXL | Yes | ||||||
enavatuzumab | IgG | TWEAK-R | |||||||
encelimab | IgG | LAG-3 | Yes | ||||||
enfortumab | IgG | Nectin-4 | |||||||
enibarcimab | IgG | Adrenomedulin | |||||||
enlimomab | Unconfirmed | CD54 | |||||||
enoblituzumab | IgG | B7-H3 | ↑ | ||||||
enokizumab | IgG | IL-9 | |||||||
enoticumab | IgG | DLL4 | Yes | ||||||
ensituximab | IgG | MUC5AC | Yes | ||||||
ensomafusp | IgG-protein fusion (type 3) | CD19 | ↓ | Yes | |||||
enuzovimab | IgG | SARS-CoV-2 | ↑ | Yes | |||||
envafolimab | dAb-Fc | PD-L1 | |||||||
epcoritamab | Bispecific IgG (type 6) | CD20 | ↓ | Yes | Yes | ||||
epitumomab | Unconfirmed | MUC1 | |||||||
epratuzumab | Unconfirmed | CD22 | |||||||
eptinezumab | IgG | CGRP | ↓ | Yes | |||||
eramkafusp | IgG-protein fusion (type 1) | CD20 | |||||||
erenumab | IgG | CGRPR | |||||||
erfonrilimab | Tandem dAb-Fc | PD-L1 | |||||||
erlizumab | F(ab')2 | CD18 | |||||||
ertumaxomab | Unconfirmed | HER2 | |||||||
etanercept | Unconfirmed | TNF alpha | |||||||
etaracizumab | IgG | Integrin alpha5/beta3 | |||||||
etesevimab | IgG | SARS-CoV-2 | ↓ | ||||||
etevritamab | Tandem scFv | EGFR | |||||||
etigilimab | IgG | TIGIT | Yes | ||||||
etokimab | IgG | IL-33 | |||||||
etrolizumab | IgG | Integrin alpha4/beta7 | Yes | ||||||
evinacumab | IgG | Angiopoietin-like 3 | Yes | ||||||
evolocumab | IgG | PCSK9 | |||||||
evorpacept | Fc fusion protein (type 1) | CD47 | ↓ | Yes | |||||
exbivirumab | IgG | Hepatitis B virus | |||||||
exidavnemab | IgG | Synuclein alpha | Yes | Yes | |||||
ezabenlimab | IgG | PD-1 | Yes | Yes | |||||
fanolesomab | Unconfirmed | CD15 | |||||||
faralimomab | Unconfirmed | Interferon alpha | |||||||
faricimab | Bispecific IgG (type 5) | VEGF | ↓ | ↓ | Yes | Yes | |||
farletuzumab | IgG | FOLR1 | |||||||
fasinumab | IgG | NGF | Yes | ||||||
favezelimab | IgG | LAG-3 | Yes | ||||||
fazpilodemab | Bispecific IgG (type 1) | FGFR1 | ↓ | Yes | |||||
feladilimab | IgG | CD278 | ↓ | Yes | |||||
felvizumab | Unconfirmed | Respiratory syncytial virus | |||||||
felzartamab | IgG | CD38 | |||||||
fezakinumab | IgG | IL-22 | Yes | ||||||
fianlimab | IgG | LAG-3 | ↓ | Yes | |||||
ficlatuzumab | IgG | HGF | |||||||
fidasimtamab | Bispecific IgG (type 1) | PD-1 | Yes | ||||||
figitumumab | IgG | IGF1R | Yes | ||||||
finotonlimab | IgG | PD-1 | Yes | ||||||
firivumab | IgG | Influenza A hemagglutinin | |||||||
fiztasovimab | IgG | CMV | |||||||
flanvotumab | IgG | GP75 | |||||||
fletikumab | IgG | IL-20 | Yes | ||||||
flotetuzumab | Diabody | CD123 | |||||||
fontolizumab | IgG | Interferon gamma | |||||||
foralumab | IgG | CD3 | ↓ | ||||||
foravirumab | IgG | Rabies virus | Yes | ||||||
fremanezumab | IgG | CGRP | ↓ | ||||||
fresolimumab | IgG | TGF beta | |||||||
frexalimab | IgG | CD40L | ↑ | ||||||
frovocimab | IgG | PCSK9 | ↓ | Yes | Yes | ||||
frunevetmab | IgG | NGF (feline) | |||||||
fulranumab | IgG | NGF | |||||||
futuximab | IgG | EGFR | Yes | ||||||
galcanezumab | IgG | CGRP | ↓ | Yes | Yes | ||||
galegenimab | Fab | HtrA1 | |||||||
galiximab | IgG | CD80 | ↑ | ||||||
gancotamab | scFv | HER2 | |||||||
ganitumab | IgG | IGF1R | |||||||
gantenerumab | IgG | Amyloid beta | |||||||
garadacimab | IgG | Factor XIIa | Yes | ||||||
garetosmab | IgG | Activin A | Yes | ||||||
garivulimab | IgG | PD-L1 | ↓ | ||||||
gatipotuzumab | IgG | MUC1 | |||||||
gatralimab | IgG | CD52 | |||||||
gavilimomab | Unconfirmed | CD147 | |||||||
gedivumab | IgG | Influenza A hemagglutinin | |||||||
gefurulimab | Tandem dAb (type 2) | C5 | |||||||
gemtuzumab | IgG | CD33 | Yes | ||||||
geptanolimab | IgG | PD-1 | Yes | Yes | |||||
gevokizumab | IgG | IL-1 beta | Yes | ||||||
giloralimab | IgG | CD40 | ↓ | ||||||
gilvetmab | IgG | PDCD1 (canine) | |||||||
gimsilumab | IgG | GM-CSF | ↑ | ||||||
ginisortamab | IgG | GREM1 | Yes | ||||||
girentuximab | IgG | Carbonic anhydrase IX | |||||||
glembatumumab | IgG | GPNMB | |||||||
glenzocimab | Fab | GP6 | |||||||
glofitamab | Fab-IgG (type 1) | CD20 | ↓ | Yes | Yes | ||||
goflikicept | Fc fusion protein (type 4) | IL-1B | Yes | ||||||
golimumab | IgG | TNF alpha | |||||||
golocdacimab | IgG | LOX-1 | ↓ | ||||||
gontivimab | Triple dAb (type 1) | Respiratory syncytial virus | |||||||
gosuranemab | IgG | Tau | Yes | Yes | |||||
gremubamab | IgG-scFv (type 4) | Pseudomonas aeruginosa | |||||||
gresonitamab | Tandem scFv-scFc | Claudin 18.2 | ↓ | Yes | |||||
grisnilimab | IgG | CD7 | |||||||
gumokimab | IgG | IL-17 | |||||||
guselkumab | IgG | IL-23 | Yes | ||||||
ianalumab | IgG | BAFF | ↑ | ||||||
ibalizumab | IgG | CD4 | |||||||
ibritumomab | Unconfirmed | CD20 | |||||||
icrucumab | IgG | VEGF-R1 | |||||||
idactamab | IgG | ASCT2 | Yes | ||||||
idarucizumab | Fab | Dabigatran | |||||||
ieramilimab | IgG | LAG-3 | Yes | Yes | |||||
ifabotuzumab | IgG | EPHA3 | ↑ | ||||||
ifinatamab | IgG | B7-H3 | |||||||
igovomab | Unconfirmed | CA125 | |||||||
iladatuzumab | IgG | CD79b | |||||||
imalumab | IgG | MIF | |||||||
imaprelimab | IgG | MCAM | ↓ | ||||||
imciromab | Unconfirmed | Cardiac myosin | |||||||
imdevimab | IgG | SARS-CoV-2 | |||||||
imgatuzumab | IgG | EGFR | Yes | ||||||
imsidolimab | IgG | IL-36R | Yes | ||||||
imvotamab | IgM with J chain fusion | CD20 | |||||||
inbakicept | Fc fusion protein (type 1) | IL-15 | |||||||
inclacumab | IgG | CD62 | ↓ | Yes | |||||
indatuximab | IgG | CD138 | |||||||
indusatumab | IgG | Guanylyl cyclase C | |||||||
inebilizumab | IgG | CD19 | ↑ | ||||||
inezetamab | IgG-scFv (type 1) | Mesothelin | ↓ | Yes | Yes | ||||
infliximab | Unconfirmed | TNF alpha | |||||||
inolimomab | Unconfirmed | CD25 | |||||||
inotuzumab | IgG | CD22 | Yes | ||||||
intetumumab | IgG | Integrin alpha5/beta3 | |||||||
ipafricept | Fc fusion protein (type 1) | WNT ligand | |||||||
iparomlimab | IgG | PD-1 | Yes | ||||||
ipilimumab | IgG | CTLA-4 | |||||||
iratumumab | IgG | CD30 | |||||||
isatuximab | IgG | CD38 | |||||||
iscalimab | IgG | CD40 | ↓ | ||||||
isecarosmab | Tandem dAb (type 2) | ADAMTS-5 | |||||||
ispectamab | IgG | BCMA | Yes | ||||||
istiratumab | IgG-scFv (type 1) | IGF1R | Yes | ||||||
itepekimab | IgG | IL-33 | Yes | ||||||
itolizumab | IgG | CD6 | |||||||
ivicentamab | Bispecific IgG (type 6) | CD37 | ↑ | Yes | Yes | ||||
ivonescimab | IgG-scFv (type 1) | PD-1 | ↓ | ||||||
ivuxolimab | IgG | OX40 | |||||||
ixekizumab | IgG | IL-17A | Yes | Yes | |||||
izalontamab | IgG-scFv (type 1) | EGFR | Yes | ||||||
izenivetmab | IgG | NGF (canine) | ↓ | ||||||
izuralimab | Heterodimeric Fab/scFv-Fc | PD-1 | ↓ | ↑ | Yes | ||||
keliximab | Unconfirmed | CD4 | |||||||
labetuzumab | IgG | CEACAM5 | |||||||
lacnotuzumab | IgG | M-CSF | |||||||
lacutamab | IgG | KIR3DL2 | ↑ | ||||||
ladiratuzumab | IgG | LIV-1 | |||||||
lampalizumab | Fab | Factor D | |||||||
lanadelumab | IgG | Plasma kallikrein | Yes | ||||||
landogrozumab | IgG | Myostatin | Yes | Yes | |||||
laprituximab | IgG | EGFR | Yes | ||||||
larcaviximab | IgG | Ebola virus | |||||||
latikafusp | IgG-protein fusion (type 2) | PD-1 | ↓ | Yes | Yes | Yes | |||
latozinemab | IgG | Sortilin | ↓ | ||||||
lebrikizumab | IgG | IL-13 | Yes | ||||||
lecanemab | IgG | Amyloid beta | |||||||
lemalesomab | IgG | NCA-90 | |||||||
lemzoparlimab | IgG | CD47 | Yes | ||||||
lenercept | Fc fusion protein (type 1) | TNF alpha | |||||||
lenvervimab | IgG | Hepatitis B virus | |||||||
lenzilumab | IgG | GM-CSF | |||||||
lepunafusp | Fab-protein fusion (type 1) | Transferrin receptor | |||||||
lerdelimumab | IgG | TGF beta | |||||||
leronlimab | IgG | CCR5 | |||||||
lesabelimab | IgG | PD-L1 | |||||||
lesofavumab | IgG | Influenza B hemagglutinin | |||||||
letaplimab | IgG | CD47 | ↓ | Yes | Yes | ||||
letolizumab | dAb-Fc | CD40L | |||||||
levilimab | IgG | IL-6R | ↓ | ↑ | |||||
lexatumumab | IgG | TRAIL-R2 | |||||||
libivirumab | IgG | Hepatitis B virus | |||||||
licaminlimab | scFv | TNF alpha | |||||||
lifastuzumab | IgG | NaPi2b | |||||||
ligelizumab | IgG | IgE | |||||||
ligufalimab | IgG | CD47 | Yes | ||||||
lilotomab | IgG | CD37 | |||||||
lintuzumab | IgG | CD33 | |||||||
linvoseltamab | Bispecific IgG (type 3) | BCMA | ↓ | Yes | Yes | ||||
lirentelimab | IgG | Siglec-8 | ↑ | ||||||
lirilumab | IgG | KIRD2 | Yes | ||||||
litifilimab | IgG | CLEC4C | Yes | ||||||
livmoniplimab | IgG | LRRC32 | Yes | Yes | |||||
lodapolimab | IgG | PD-L1 | ↓ | ||||||
lodelcizumab | IgG | PCSK9 | ↓ | ||||||
lokivetmab | IgG | IL-31 | |||||||
lomtegovimab | IgG | SARS-CoV-2 | Yes | ||||||
loncastuximab | IgG | CD19 | Yes | ||||||
lonigutamab | IgG | IGF1R | Yes | ||||||
lorigerlimab | Diabody-Fc (type 1) | PD-1 | ↑ | Yes | |||||
lorukafusp | IgG-protein fusion (type 1) | GD2 | |||||||
lorvotuzumab | IgG | CD56 | |||||||
losatuxizumab | IgG | EGFR | |||||||
lucatumumab | IgG | CD40 | Yes | ||||||
lulizumab | dAb | CD28 | |||||||
lumiliximab | Unconfirmed | CD23 | |||||||
lumretuzumab | IgG | HER3 | Yes | ||||||
lupartumab | IgG | LYPD3 | Yes | ||||||
luspatercept | Fc fusion protein (type 1) | ActRIIA ligands | |||||||
lusvertikimab | IgG | IL-7R | Yes | ||||||
lutikizumab | Fv-IgG | IL-1 alpha | ↓ | ||||||
luveltamab | IgG | FOLR1 | Yes | ||||||
maftivimab | IgG | Ebola virus | |||||||
magrolimab | IgG | CD47 | Yes | ||||||
manelimab | IgG | PD-L1 | ↓ | ||||||
manfidokimab | IgG | IL-4R | Yes | ||||||
mapatumumab | Unconfirmed | TRAIL-R1 | |||||||
margetuximab | IgG | HER2 | ↑ | ||||||
marstacimab | IgG | Tissue factor pathway inhibitor | ↓ | Yes | |||||
masavibart | IgG | SARS-CoV-2 | ↓ | ↑ | |||||
maslimomab | Unconfirmed | TCR | |||||||
matuzumab | Unconfirmed | EGFR | |||||||
mavrilimumab | IgG | CD116 | |||||||
mazorelvimab | IgG | Rabies virus | |||||||
mecbotamab | IgG | AXL | Yes | ||||||
melredableukin | IgG-protein fusion (type 1) | IL-2R | ↓ | Yes | |||||
melrilimab | IgG | IL-33R | ↓ | ||||||
mepolizumab | IgG | IL-5 | |||||||
metelimumab | IgG | TGF beta | |||||||
mezagitamab | IgG | CD38 | |||||||
mibavademab | IgG | LEPR | Yes | ||||||
milatuzumab | IgG | CD74 | |||||||
minretumomab | Unconfirmed | Tag-72 | |||||||
mipasetamab | IgG | AXL | Yes | ||||||
miptenalimab | IgG | LAG-3 | Yes | Yes | |||||
mirikizumab | IgG | IL-23 | ↓ | Yes | Yes | ||||
miromavimab | IgG | Rabies virus | |||||||
mirvetuximab | IgG | FOLR1 | Yes | ||||||
mirzotamab | IgG | B7-H3 | ↓ | ||||||
mitazalimab | IgG | CD40 | |||||||
mitumomab | Unconfirmed | GD3 | |||||||
modakafusp | IgG-protein fusion (type 1) | CD38 | Yes | ||||||
modotuximab | IgG | EGFR | Yes | ||||||
mogamulizumab | IgG | CCR4 | |||||||
monalizumab | IgG | CD159a | Yes | ||||||
morolimumab | Unconfirmed | Rhesus D | |||||||
mosunetuzumab | Bispecific IgG (type 1) | CD20 | ↓ | Yes | |||||
motavizumab | IgG | Respiratory syncytial virus | |||||||
moxetumomab | Fv-protein fusion | CD22 | |||||||
mupadolimab | IgG | CD73 | ↓ | ||||||
murlentamab | IgG | Mullerian inhibiting substance type II | |||||||
muromonab | Unconfirmed | CD3 | |||||||
nacolomab | Unconfirmed | Colorectal tumor antigen | |||||||
nadecnemab | IgG | GFRa3 | Yes | ||||||
nadunolimab | IgG | IL-1R accessory protein | Yes | ||||||
namilumab | IgG | GM-CSF | |||||||
naptumomab | Fab-protein fusion (type 1) | TPBG | |||||||
naratuximab | IgG | CD37 | Yes | ||||||
narnatumab | IgG | RON8 | |||||||
narsoplimab | IgG | MASP-2 | Yes | ||||||
natalizumab | IgG | Integrin alpha4 | |||||||
navicixizumab | Bispecific IgG (type 2) | DLL4 | Yes | ||||||
navivumab | IgG | Influenza A hemagglutinin | |||||||
naxitamab | IgG | GD2 | |||||||
nebacumab | Unconfirmed | Endotoxin | |||||||
necitumumab | IgG | EGFR | |||||||
nemolizumab | IgG | IL-31R alpha | Yes | ||||||
nepuvibart | IgG | SARS-CoV-2 | ↓ | ↑ | |||||
nerelimomab | Unconfirmed | TNF alpha | |||||||
nesvacumab | IgG | Ang-2 | |||||||
netakimab | IgG | IL-17 | ↑ | ||||||
nimacimab | IgG | Cannabinoid 1 receptor | Yes | ||||||
nimotuzumab | IgG | EGFR | |||||||
nipocalimab | IgG | FcRn | ↓ | Yes | Yes | ||||
nirsevimab | IgG | Respiratory syncytial virus | ↑ | ||||||
nivatrotamab | IgG-scFv (type 3) | GD2 | ↓ | ||||||
nivolumab | IgG | PD-1 | Yes | ||||||
nofazinlimab | IgG | PD-1 | Yes | ||||||
nofetumomab | Unconfirmed | GP40 | |||||||
nurulimab | IgG | CTLA-4 | Yes | ||||||
obexelimab | IgG | CD19 | ↑ | ||||||
obiltoxaximab | IgG | Bacillus anthrax | |||||||
obinutuzumab | IgG | CD20 | |||||||
obrindatamab | Diabody-Fc (type 2) | B7-H3 | ↓ | Yes | Yes | ||||
ocaratuzumab | IgG | CD20 | ↑ | Yes | |||||
ociperlimab | IgG | TIGIT | |||||||
ocrelizumab | IgG | CD20 | |||||||
odesivimab | IgG | Ebola virus | |||||||
odronextamab | Bispecific IgG (type 3) | CD20 | ↓ | Yes | Yes | ||||
odulimomab | Unconfirmed | CD11a | |||||||
ofatumumab | IgG | CD20 | |||||||
ogalvibart | IgG | SARS-CoV-2 | ↑ | Yes | |||||
olamkicept | Fc fusion protein (type 1) | IL-6 | ↓ | ||||||
olaratumab | IgG | PDGF alpha | |||||||
oleclumab | IgG | CD73 | ↓ | ||||||
olendalizumab | IgG | C5 | |||||||
olinvacimab | IgG | VEGF-R2 | |||||||
olokizumab | IgG | IL-6 | Yes | ||||||
omalizumab | IgG | IgE | |||||||
omburtamab | IgG | CD276 | |||||||
omodenbamab | IgG | Staphylococcus aureus | |||||||
onartuzumab | Heterodimeric Fab-Fc | HGFR | Yes | ||||||
onfekafusp | scFv-protein fusion | Fibronectin | |||||||
ongericimab | IgG | PCSK9 | Yes | ||||||
ontamalimab | IgG | MADCAM | |||||||
ontorpacept | Fc fusion protein (type 1) | CD47 | |||||||
ontuxizumab | IgG | Endosialin | Yes | ||||||
onvatilimab | IgG | VISTA | |||||||
opicinumab | IgG | LINGO | ↓ | Yes | |||||
opinercept | Fc fusion protein (type 1) | TNF alpha | |||||||
oportuzumab | scFv-protein fusion | EpCAM | |||||||
opucolimab | IgG | PD-L1 | ↓ | ||||||
ordesekimab | IgG | IL-15 | |||||||
oregovomab | Unconfirmed | CA125 | |||||||
orilanolimab | IgG | FcRn | Yes | Yes | |||||
ormutivimab | IgG | Rabies virus | |||||||
orticumab | IgG | Oxidized LDL | |||||||
osemitamab | IgG | Claudin 18.2 | |||||||
osocimab | IgG | Factor XIa | Yes | ||||||
otelixizumab | IgG | CD3 | ↓ | ||||||
otilimab | IgG | GM-CSF | |||||||
otlertuzumab | scFv-Fc | CD37 | |||||||
oxelumab | IgG | OX40L | Yes | ||||||
ozanezumab | IgG | NOGO-A | ↓ | ||||||
ozoralizumab | Triple dAb (type 2) | TNF alpha | |||||||
ozuriftamab | IgG | ROR2 | Yes | ||||||
pabinafusp | IgG-protein fusion (type 1) | Transferrin receptor | |||||||
pacanalotamab | Tandem scFv | BCMA | |||||||
pacmilimab | Protease activated IgG | PD-L1 | Yes | Yes | |||||
pagibaximab | Unconfirmed | Lipoteichoic acid | |||||||
palivizumab | Unconfirmed | Respiratory syncytial virus | |||||||
pamrevlumab | IgG | CTGF | Yes | ||||||
panitumumab | IgG | EGFR | |||||||
panobacumab | IgM | Pseudomonas aeruginosa | |||||||
paridiprubart | IgG | TLR4 | ↑ | ||||||
parsatuzumab | IgG | EGFL7 | |||||||
pascolizumab | IgG | IL-4 | |||||||
pasotuxizumab | Tandem scFv | PSMA | |||||||
pateclizumab | IgG | Lymphotoxin alpha | Yes | ||||||
patritumab | IgG | HER3 | |||||||
pavurutamab | Tandem scFv-scFc | BCMA | ↓ | Yes | |||||
pelgifatamab | IgG | PSMA | |||||||
pembrolizumab | IgG | PD-1 | Yes | ||||||
penpulimab | IgG | PD-1 | ↓ | ||||||
pepinemab | IgG | SEMA4D | Yes | ||||||
perakizumab | IgG | IL-17A | ↓ | ||||||
peresolimab | IgG | PD-1 | |||||||
pertuzumab | IgG | HER2 | Yes | ||||||
petosemtamab | Bispecific IgG (type 2) | EGFR | Yes | Yes | |||||
pexelizumab | scFv | C5 | |||||||
pidilizumab | IgG | DLL1 | |||||||
pimivalimab | IgG | PD-1 | Yes | ||||||
pimurutamab | IgG | EGFR | |||||||
pinatuzumab | IgG | CD22 | |||||||
pintumomab | Unconfirmed | Adenocarcinoma antigen | |||||||
pivekimab | IgG | IL-3R | Yes | Yes | |||||
placulumab | dAb-Fc | TNF alpha | |||||||
plamotamab | Heterodimeric Fab/scFv-Fc | CD20 | ↓ | Yes | |||||
plonmarlimab | IgG | GM-CSF | |||||||
plozalizumab | IgG | CCR2 | ↓ | ||||||
plutavimab | IgG | SARS-CoV-2 | ↓ | ||||||
polatuzumab | IgG | CD79b | |||||||
ponezumab | IgG | Amyloid beta | ↓ | ||||||
ponsegromab | IgG | Growth Differentiation Factor 15 | ↓ | Yes | |||||
porgaviximab | IgG | Ebola virus | |||||||
posdinemab | IgG | Tau | |||||||
pozelimab | IgG | C5 | Yes | ||||||
praluzatamab | Protease activated IgG | CD166 | Yes | ||||||
prasinezumab | IgG | Synuclein alpha | |||||||
prezalumab | IgG | CD28 | |||||||
priliximab | Unconfirmed | CD4 | |||||||
pritoxaximab | IgG | Shiga-like toxin | |||||||
pritumumab | IgG | Vimentin | |||||||
prolgolimab | IgG | PD-1 | ↓ | ||||||
pucotenlimab | IgG | PD-1 | ↑ | Yes | |||||
pulocimab | IgG | VEGF-R2 | |||||||
quavonlimab | IgG | CTLA-4 | |||||||
quetmolimab | IgG | Fractalkine | ↓ | ||||||
quilizumab | IgG | IgE | |||||||
quisovalimab | IgG | LIGHT | ↓ | Yes | Yes | ||||
racotumomab | IgG | GM3 | |||||||
radretumab | scFv-protein fusion | Fibronectin | |||||||
rafivirumab | IgG | Rabies virus | Yes | ||||||
ragifilimab | IgG | GITR | Yes | ||||||
ralpancizumab | IgG | PCSK9 | ↓ | ||||||
ramatercept | Fc fusion protein (type 1) | ActRIIA ligands | ↓ | ||||||
ramucirumab | IgG | VEGF-R2 | Yes | ||||||
ranevetmab | IgG | NGF (canine) | |||||||
ranibizumab | Fab | VEGF | |||||||
ravagalimab | IgG | CD40 | ↓ | ↑ | |||||
ravulizumab | IgG | C5 | |||||||
raxibacumab | Unconfirmed | Bacillus anthrax | |||||||
recaticimab | IgG | PCSK9 | ↑ | ||||||
refanezumab | IgG | Myelin associated glycoprotein | ↓ | ||||||
regavirumab | Unconfirmed | Herpes virus | |||||||
regdanvimab | IgG | SARS-CoV-2 | Yes | ||||||
relatlimab | IgG | LAG-3 | Yes | ||||||
relfovetmab | IgG | NGF (feline) | |||||||
remtolumab | Fv-IgG | TNF alpha | |||||||
reozalimab | Bispecific IgG (type 4) | PD-1 | ↓ | Yes | |||||
reslizumab | Unconfirmed | IL-5 | |||||||
retifanlimab | IgG | PD-1 | Yes | Yes | |||||
retlirafusp | IgG-protein fusion (type 1) | PD-L1 | ↓ | Yes | Yes | ||||
revdofilimab | IgG | OX40 | |||||||
rilonacept | Fc fusion protein (type 2) | IL-1 alpha | |||||||
rilotumumab | IgG | HGF | |||||||
rimteravimab | dAb-Fc | SARS-CoV-2 | ↓ | Yes | |||||
rinucumab | IgG | PDGF beta | Yes | ||||||
ripertamab | IgG | CD20 | |||||||
risankizumab | IgG | IL-23 | ↓ | Yes | |||||
rituximab | IgG | CD20 | |||||||
rivabazumab | Fab | Pseudomonas aeruginosa | Yes | ||||||
robatumumab | IgG | IGF1R | |||||||
rocatinlimab | IgG | OX40 | |||||||
roledumab | IgG | Rhesus D | |||||||
rolinsatamab | IgG | Prolactin receptor | Yes | ||||||
romilkimab | Fv-IgG | IL-4 | ↓ | Yes | Yes | ||||
romlusevimab | IgG | SARS-CoV-2 | ↑ | ||||||
romosozumab | IgG | Sclerostin | |||||||
rontalizumab | IgG | Interferon alpha | |||||||
rosmantuzumab | IgG | RSPO3 | |||||||
rosnilimab | IgG | PD-1 | |||||||
rosopatamab | IgG | PSMA | |||||||
rovalpituzumab | IgG | DLL3 | Yes | ||||||
rovelizumab | IgG | CD18 | |||||||
rozanolixizumab | IgG | FcRn | Yes | ||||||
rozibafusp | IgG-protein fusion (type 1) | BAFF | |||||||
rulonilimab | IgG | PD-1 | ↓ | ↑ | |||||
runimotamab | Bispecific IgG (type 1) | HER2 | ↓ | Yes | |||||
ruplizumab | IgG | CD40L | Yes | ||||||
sabatolimab | IgG | TIM-3 | Yes | Yes | |||||
sacituzumab | IgG | TROP-2 | |||||||
samalizumab | IgG | CD200 | |||||||
samrotamab | IgG | LRRC15 | |||||||
sarilumab | IgG | IL-6R | |||||||
sasanlimab | IgG | PD-1 | Yes | ||||||
satralizumab | IgG | IL-6R | Yes | ||||||
satumomab | IgG | Tag-72 | Yes | ||||||
secukinumab | IgG | IL-17A | |||||||
selicrelumab | IgG | CD40 | |||||||
semorinemab | IgG | Tau | ↑ | Yes | |||||
semzuvolimab | IgG | CD4 | ↓ | ||||||
serclutamab | IgG | EGFR | Yes | ||||||
seribantumab | IgG | HER3 | |||||||
serplulimab | IgG | PD-1 | Yes | ||||||
setoxaximab | IgG | Shiga-like toxin | |||||||
setrusumab | IgG | Sclerostin | |||||||
sevirumab | Unconfirmed | CMV | |||||||
sibeprenlimab | IgG | APRIL | |||||||
sibrotuzumab | Unconfirmed | FAP | |||||||
sifalimumab | IgG | Interferon alpha | |||||||
siltuximab | IgG | IL-6 | |||||||
simlukafusp | IgG-protein fusion (type 2) | FAP | ↓ | Yes | Yes | ||||
simridarlimab | Heterodimeric Fab/scFv-Fc | PD-L1 | ↓ | Yes | Yes | ||||
simtuzumab | IgG | LOXL2 | Yes | ||||||
sintilimab | IgG | PD-1 | Yes | ||||||
siplizumab | Unconfirmed | CD2 | |||||||
sirexatamab | IgG | DKK1 | ↓ | Yes | Yes | ||||
sirtratumab | IgG | SLITRK6 | |||||||
sirukumab | IgG | IL-6 | |||||||
socazolimab | IgG | PD-L1 | |||||||
sofituzumab | IgG | MUC16 | |||||||
solanezumab | IgG | Amyloid beta | |||||||
solitomab | Tandem scFv | EpCAM | |||||||
sonelokimab | Triple dAb (type 3) | IL-17A | |||||||
sontuzumab | Unconfirmed | MUC1 | |||||||
sotatercept | Fc fusion protein (type 1) | ActRIIA ligands | ↓ | ||||||
sotevtamab | IgG | Clusterin | |||||||
sotigalimab | IgG | CD40 | ↑ | ||||||
sotrovimab | IgG | SARS-CoV-2 | ↑ | ||||||
sozinibercept | Fc fusion protein (type 1) | VEGF-R3 | |||||||
spartalizumab | IgG | PD-1 | Yes | Yes | |||||
spesolimab | IgG | IL-36R | ↓ | ||||||
stamulumab | IgG | Myostatin | |||||||
suciraslimab | IgG | CD22 | |||||||
sudubrilimab | IgG | PD-1 | ↓ | Yes | |||||
sugemalimab | IgG | PD-L1 | Yes | ||||||
sulesomab | Unconfirmed | NCA-90 | |||||||
suptavumab | IgG | Respiratory syncytial virus | |||||||
surzebiclimab | IgG | TIM-3 | ↓ | ||||||
sutimlimab | IgG | C1s | ↓ | Yes | |||||
suvizumab | IgG | HIV gp120 | |||||||
suvratoxumab | IgG | Staphylococcus aureus | ↑ | ||||||
tabalumab | IgG | BLys | Yes | Yes | |||||
tabituximab | IgG | Frizzled homolog 10 | |||||||
tacatuzumab | IgG | Alpha fetoprotein | |||||||
tadocizumab | Fab | Integrin alpha2b/beta3 | |||||||
tafasitamab | IgG | CD19 | ↑ | ||||||
tafolecimab | IgG | PCSK9 | Yes | ||||||
tagitanlimab | IgG | PD-L1 | ↓ | ||||||
talacotuzumab | IgG | IL-3R | ↑ | ||||||
talizumab | IgG | IgE | |||||||
talquetamab | Bispecific IgG (type 6) | GPCR5D | ↓ | Yes | Yes | ||||
tamgiblimab | IgG | TIGIT | ↓ | Yes | Yes | ||||
tamrintamab | IgG | DPEP3 | Yes | Yes | |||||
tamtuvetmab | IgG | CD52 | |||||||
tanezumab | IgG | NGF | ↓ | ||||||
taplitumomab | Unconfirmed | CD19 | |||||||
tarcocimab | IgG | VEGF | ↓ | Yes | |||||
tarextumab | IgG | Notch-2/Notch-3 | |||||||
tarlatamab | Tandem scFv-scFc | DLL3 | ↓ | Yes | Yes | ||||
tavolimab | IgG | OX40 | |||||||
tebentafusp | scFv-TCR fusion | gp100 | |||||||
tebotelimab | Diabody-Fc (type 1) | PD-1 | ↑ | Yes | |||||
tecaginlimab | Bispecific IgG (type 6) | CD40 | ↓ | Yes | Yes | ||||
teclistamab | Bispecific IgG (type 6) | BCMA | ↓ | Yes | Yes | Yes | |||
tefibazumab | Unconfirmed | Staphylococcus aureus | |||||||
telazorlimab | IgG | OX40 | |||||||
telimomab | Unconfirmed | CD5 | |||||||
telisotuzumab | IgG | HGFR | Yes | Yes | |||||
telitacicept | Fc fusion protein (type 1) | BLyS/APRIL | ↓ | ||||||
temelimab | IgG | HERV | Yes | ||||||
tenatumomab | IgG | Tenascin-C | |||||||
teneliximab | IgG | CD40 | |||||||
teplizumab | IgG | CD3 | ↓ | ||||||
tepoditamab | Bispecific IgG (type 2) | CLEC12A | ↓ | Yes | Yes | ||||
teprotumumab | IgG | IGF1R | |||||||
teropavimab | IgG | HIV gp120 | ↑ | Yes | |||||
tesidolumab | IgG | C5 | ↓ | ||||||
tesnatilimab | IgG | CD314 | Yes | ||||||
tezepelumab | IgG | Thymic stromal lymphopoietin | |||||||
tibulizumab | IgG-scFv (type 1) | BAFF | Yes | Yes | Yes | ||||
tidutamab | Heterodimeric Fab/scFv-Fc | SSTR2 | ↓ | Yes | |||||
tifcemalimab | IgG | BTLA | Yes | ||||||
tigatuzumab | IgG | TRAIL-R2 | |||||||
tilavonemab | IgG | Tau | Yes | ||||||
tildrakizumab | IgG | IL-23 | |||||||
tilogotamab | IgG | DR5 | ↑ | Yes | |||||
tilvestamab | IgG | AXL | |||||||
timigutuzumab | IgG | HER2 | |||||||
timolumab | IgG | Vascular adhesion protein-1 | ↓ | Yes | |||||
tinurilimab | IgG | CEACAM6 | Yes | ||||||
tiragolumab | IgG | TIGIT | |||||||
tirnovetmab | IgG | IL-31 (canine) | |||||||
tislelizumab | IgG | PD-1 | ↓ | Yes | |||||
tisotumab | IgG | Thromboplastin | |||||||
tixagevimab | IgG | SARS-CoV-2 | ↓ | ↑ | |||||
tocilizumab | IgG | IL-6R | Yes | ||||||
tomaralimab | IgG | TLR2 | Yes | ||||||
tomuzotuximab | IgG | EGFR | |||||||
toralizumab | Unconfirmed | CD40L | |||||||
toripalimab | IgG | PD-1 | Yes | ||||||
torudokimab | IgG | IL-33 | ↓ | Yes | Yes | ||||
tosatoxumab | IgG | Staphylococcus aureus | |||||||
tositumomab | Unconfirmed | CD20 | |||||||
tovetumab | IgG | PDGF alpha | |||||||
tozorakimab | IgG | IL-33 | |||||||
tralokinumab | IgG | IL-13 | |||||||
trastuzumab | IgG | HER2 | Yes | ||||||
trebananib | Fc fusion protein (type 6) | Ang-1/Ang-2 | |||||||
tregalizumab | IgG | CD4 | |||||||
tremelimumab | IgG | CTLA-4 | |||||||
trevogrumab | IgG | Myostatin | Yes | ||||||
trinbelimab | IgG | Rhesus D | Yes | ||||||
trontinemab | Fab-IgG (type 3) | Amyloid beta | Yes | Yes | |||||
tucotuzumab | IgG-protein fusion (type 1) | EpCAM | |||||||
tulinercept | Fc fusion protein (type 1) | TNF alpha | |||||||
tusamitamab | IgG | CEACAM5 | Yes | ||||||
tuvirumab | Unconfirmed | Hepatitis B virus | |||||||
tuvonralimab | IgG | CTLA-4 | Yes | ||||||
ubamatamab | Bispecific IgG (type 3) | MUC16 | ↓ | Yes | Yes | ||||
ublituximab | IgG | CD20 | |||||||
ulenistamab | IgG | PAUF | Yes | ||||||
uliledlimab | IgG | CD73 | ↓ | ||||||
ulocuplumab | IgG | CXCR4 | Yes | Yes | |||||
unasnemab | IgG | Repulsive Guidance Molecule A | |||||||
upanovimab | IgG | SARS-CoV-2 | ↓ | ||||||
upifitamab | IgG | NaPi2b | Yes | ||||||
urabrelimab | IgG | CD47 | Yes | ||||||
urelumab | IgG | 4-1BB | Yes | ||||||
urtoxazumab | IgG | Shiga-like toxin | |||||||
ustekinumab | IgG | IL-12/IL-23 | |||||||
utomilumab | IgG | 4-1BB | |||||||
vadastuximab | IgG | CD33 | Yes | ||||||
valanafusp | IgG-protein fusion (type 1) | Insulin receptor | Yes | ||||||
vandortuzumab | IgG | STEAP1 | |||||||
vantictumab | IgG | Frizzled homolog 7 | Yes | ||||||
vanucizumab | Bispecific IgG (type 5) | Ang-2 | Yes | ||||||
vapaliximab | Unconfirmed | Vascular adhesion protein-1 | |||||||
varisacumab | IgG | VEGF | |||||||
varlilumab | IgG | CD27 | |||||||
vatelizumab | IgG | Integrin alpha2/beta1 | |||||||
vedolizumab | IgG | Integrin alpha4/beta7 | ↓ | ||||||
veltuzumab | IgG | CD20 | |||||||
vepalimomab | Unconfirmed | Vascular adhesion protein-1 | |||||||
vepsitamab | Tandem scFv-scFc | MUC17 | ↓ | Yes | |||||
vesencumab | IgG | Neuropilin 1 | |||||||
vibecotamab | Heterodimeric Fab/scFv-Fc | CD123 | ↓ | Yes | |||||
vibostolimab | IgG | TIGIT | |||||||
vilobelimab | IgG | C5 | |||||||
visilizumab | IgG | CD3 | ↓ | Yes | |||||
visugromab | IgG | GDF15 | Yes | Yes | |||||
vixarelimab | IgG | Oncostatin M receptor | ↓ | Yes | Yes | ||||
vixtimotamab | Tandem scFv | CD33 | |||||||
vobarilizumab | Tandem dAb (type 2) | IL-6R | |||||||
vobramitamab | IgG | B7-H3 | |||||||
vofatamab | IgG | FGFR3 | |||||||
volagidemab | IgG | GCGR | |||||||
volociximab | IgG | Integrin alpha5/beta1 | |||||||
vonlerolizumab | IgG | OX40 | |||||||
vopratelimab | IgG | CD278 | |||||||
vorsetuzumab | IgG | CD70 | |||||||
votumumab | Unconfirmed | CTAA16.88 | |||||||
voxalatamab | Bispecific IgG (type 6) | PSMA | ↓ | Yes | Yes | ||||
vudalimab | Heterodimeric Fab/scFv-Fc | PD-1 | ↓ | ↑ | Yes | ||||
vulinacimab | IgG | VEGF-R2 | |||||||
vunakizumab | IgG | IL-17A | |||||||
xeligekimab | IgG | IL-17A | Yes | ||||||
xentuzumab | IgG | IGF1/IGF2 | Yes | ||||||
zagotenemab | IgG | Tau | ↓ | Yes | Yes | ||||
zalifrelimab | IgG | CTLA-4 | |||||||
zalutumumab | IgG | EGFR | |||||||
zamerovimab | IgG | Rabies virus | |||||||
zampilimab | IgG | Transglutaminase 2 | Yes | ||||||
zanidatamab | Heterodimeric Fab/scFv-Fc | HER2 | Yes | Yes | |||||
zanolimumab | Unconfirmed | CD4 | |||||||
zansecimab | IgG | Ang-2 | ↓ | Yes | Yes | ||||
zelminemab | IgG | PAC1 receptor type 1 | ↓ | ||||||
zeluvalimab | IgG | PD-1 | ↓ | Yes | |||||
zenocutuzumab | Bispecific IgG (type 2) | HER2 | Yes | Yes | |||||
zilovertamab | IgG | ROR1 | |||||||
ziltivekimab | IgG | IL-6 | ↑ | ||||||
zimberelimab | IgG | PD-1 | Yes | ||||||
zinlirvimab | IgG | HIV gp120 | ↑ | Yes | |||||
ziralimumab | Unconfirmed | CD147 | |||||||
zolbetuximab | IgG | Claudin 18.2 | |||||||
zolimomab | Unconfirmed | CD5 | |||||||
zuberitamab | IgG | CD20 |
Licensing - STR technology is available to license
We are not involved in the research and development of our own biological therapeutics. Instead, it is our strong belief that the STR technology can be of real benefit to a large proportion of antibody and Fc fusion proteins currently being developed. We are therefore actively seeking to license our technology widely on affordable terms with non-exclusive research and commercial licenses available. Payments are based on a few simple success-based milestones with no royalties.