Analysis of antibody and Fc-fusion protein INNs

With our general interest in antibody engineering and particularly Fc silencing we set out to analyse the Fc mutations that have been utilised in the clinic. Our efforts to obtain this information from other publicly available resources turned out to be fruitless and so instead we systematically cataloged, verified, analysed and annotated all antibody and Fc fusion proteins that have a registered international non-proprietary name (INN) with the World Health Organisation (WHO). We have amassed sequence information for over 800 antibody-based biologics and provide information on the primary amino acid sequence, design format, isotype, subtype, allotype and mutations. The searchable table below provides an overview of this information. Much more detailed information can be obtained from our publication and accompanying downloadable spreadsheet which can be accessed from the mAbs journal by clicking the image to the right. 

INNFormatAntigenEffector functionHalf-lifeHeterodimerizationSite specific conjStabilizedC-term truncationOther
abagovomabIgGidiotype of anti-CA125
abataceptFc fusion protein (type 1)CD80/CD86
abciximabUnconfirmedGPIIB/IIIA
abelacimabIgGFactor XI↓
abituzumabIgGIntegrin alpha5↓
abrezekimabFabIL-13
abrilumabIgGIntegrin alpha4/beta7
acapatamabTandem scFv-scFcPSMA↓Yes
acasunlimabBispecific IgG (type 6)PD-L1↓Yes Yes
acazicolceptFc fusion protein (type 1)CD278/CD28↓Yes
acrixolimabIgGPD-1Yes
actoxumabIgGClostridium difficile enterotoxin B
adalimumabUnconfirmedTNF alpha
adebrelimabIgGPD-L1↓Yes
adecatumumabIgGEpCAM
adintrevimabIgGSARS-CoV-2↑
aducanumabIgGAmyloid betaYes
afasevikumabIgGIL-17
afelimomabUnconfirmedTNF alpha
afliberceptFc fusion protein (type 1)VEGFYesYes
alacizumabdi-Fab'VEGF-R2
alefaceptFc fusion protein (type 1)CD2
alemtuzumabIgGCD52
alirocumabIgGPCSK9Yes
alnuctamabFab-IgG (type 1)BCMA↓YesYes
alomfilimabIgGCD278
alsevalimabIgGB7-H4↑
altumomabUnconfirmedCEACAM5
amatuximabIgGMesothelin
amivantamabBispecific IgG (type 6)EGFRYes
amlitelimabIgGOX40L↓Yes
amubarvimabIgGSARS-CoV-2↑
anatumomabUnconfirmedGP72
anbenitamabBispecific IgG (type 2)HER2Yes
andecaliximabIgGMMP9Yes
anetumabIgGMesothelinYes
anifrolumabIgGInterferon receptor↓
anivovetmabIgGVP2 (canine)
anrukinzumabIgGIL-13↓
anselamimabIgGAmyloid
ansuvimabIgGEbola virus
anumigilimabIgGCD114Yes
apamistamabIgGCD45
apitegromabIgGMyostatinYesYes
apolizumabUnconfirmedHLA-DR
aprutumabIgGFGFR2Yes
arcitumomabIgGCEACAM5
ascrinvacumabIgGALK1
aselizumabIgGCD62L
asfotaseFc fusion protein (type 1)hypophosphatasia
astegolimabIgGIL-33R
asunerceptFc fusion protein (type 1)CD95L
ataciceptFc fusion protein (type 1)BLyS/APRIL↓
atezolizumabIgGPD-L1↓
atibuclimabIgGCD14
atidortoxumabIgGStaphylococcus aureusYes
atinumabIgGNOGO-A
atoltivimabIgGEbola virus
atorolimumabUnconfirmedRhesus D
avdoralimabIgGC5aR↓
avelumabIgGPD-L1
avizakimabIgGIL-21↑
axatilimabIgGCD115Yes
azintuxizumabIgGSLAMF7
bafisontamabFab-IgG (type 2)EGFR
balstilimabIgGPD-1Yes
baminerceptFc fusion protein (type 1)Lymphotoxin betaYes
bamlanivimabIgGSARS-CoV-2
bapineuzumabIgGAmyloid betaYes
bapotulimabIgGILDR2Yes
barecetamabIgGHER3Yes
barzolvolimabIgGCD117↓↑Yes
basiliximabUnconfirmedCD25
batiraxceptFc fusion protein (type 1)GAS6Yes
batoclimabIgGFcRn↓Yes
bavituximabIgGPhosphatidylserineYes
bavunalimabHeterodimeric Fab/scFv-FcCTLA-4↓↑Yes
bebtelovimabIgGSARS-CoV-2
bectumomabUnconfirmedCD22
bedinvetmabIgGNGF (canine)↓
befovacimabIgGTissue factor pathway inhibitorYes
begelomabIgGDPP4
belantamabIgGBCMA↑
belataceptFc fusion protein (type 1)CD80/CD86
belimumabIgGBLys
beludavimabIgGSARS-CoV-2↑↑
bemarituzumabIgGFGFR2↑
benralizumabIgGIL-5
bentracimabFabIL-5R
benufutamabIgGDR5↑Yes
bepranemabIgGTauYes
berlimatoxumabIgGStaphylococcus aureusYes
bermekimabIgGIL-1 alpha
bersanlimabIgGCD54
bertilimumabUnconfirmedEotaxin-1
besilesomabUnconfirmedNCA-95
betifisolimabIgGPD-L1↓
bevacizumabIgGVEGF
bexmarilimabIgGClever-1↓Yes
bezlotoxumabIgGClostridium difficile enterotoxin B
biciromabUnconfirmedFibrin
bifikafuspscFv-protein fusionFibronectin
bimagrumabIgGActRIIA ligands↓
bimekizumabIgGIL-17A/IL-17F
bintrafuspIgG-protein fusion (type 1)PD-L1Yes
birtamimabIgGAmyloid
bivatuzumabUnconfirmedCD44v6
bleselumabIgGCD40↓Yes
blinatumomabTandem scFvCD19
blisibimodFc fusion protein (type 1)BAFF
blontuvetmabIgGMS4A1
blosozumabIgGSclerostinYesYes
bococizumabIgGPCSK9↓
botensilimabIgGCTLA-4↑Yes
brazikumabIgGIL-23
brentuximabIgGCD30Yes
briakinumabIgGIL-12 beta
briobaceptFc fusion protein (type 1)BLysYes
briquilimabIgGCD117↓
brodalumabIgGIL-17RA
brolucizumabscFvVEGF
brontictuzumabIgGNotch-1
budigalimabIgGPD-1↓
burfiralimabIgGVimentin
burosumabIgGFGF23
cabiralizumabIgGCD115Yes
cadonilimabIgG-scFv (type 1)PD-1↓
camidanlumabIgGCD25
camoteskimabIgGIL-18↓
camrelizumabIgGPD-1Yes
canakinumabIgGIL-1 beta
cantuzumabIgGMUC1
caplacizumabTandem dAb (type 1)von Willebrand factor
capromabUnconfirmedPSMA
carlumabIgGCCL2
carotuximabIgGEndoglin
casirivimabIgGSARS-CoV-2
catumaxomabUnconfirmedEpCAM
cedelizumabUnconfirmedCD4
cemiplimabIgGPD-1Yes
cendakimabIgGIL-13↓
cergutuzumabIgG-protein fusion (type 2)CEACAM5↓YesYes
certolizumabFabTNF alpha
cetrelimabIgGPD-1Yes
cetuximabIgGEGFR
cevostamabBispecific IgG (type 1)FcRL5↓Yes
cibisatamabFab-IgG (type 1)CEACAM5↓Yes
cifurtilimabIgGCD40
cilgavimabIgGSARS-CoV-2↓↑
cinpanemabIgGSynuclein alphaYes
cinrebafuspIgG-protein fusion (type 1)HER2↓Yes
cirevetmabIgGTGF beta (canine)↓
citatuzumabFab-protein fusion (type 2)EpCAM
cixutumumabIgGIGF1R
clazakizumabIgGIL-6↓
clenoliximabUnconfirmedCD4
clervonafuspFab-protein fusion (type 1)SLC29A2
clesrovimabIgGRespiratory syncytial virus↑
clivatuzumabIgGMUC1
cobolimabIgGTIM-3Yes
codrituzumabIgGGPC3
cofetuzumabIgGPTK7Yes
coltuximabIgGCD19
conatumumabIgGTRAIL-R2
conberceptFc fusion protein (type 1)VEGF↑
concizumabIgGTissue factor pathway inhibitorYes
coprelotamabIgGHER2
cosfroviximabIgGEbola virus
cosibelimabIgGPD-L1
crefmirlimabMinibodyCD8AYes
crenezumabIgGAmyloid betaYesYes
crexavibartIgGSARS-CoV-2↑Yes
crizanlizumabIgGCD62↓
crotedumabIgGGCGRYes
crovalimabIgGC5↓↑YesYes
cudarolimabIgGOX40Yes
cusatuzumabIgGCD70↑
dacetuzumabIgGCD40
daclizumabIgGCD25
dafsolimabIgGCD3
dalanterceptFc fusion protein (type 1)BMP9/BMP10↓Yes
dalotuzumabIgGIGF1R
dalutrafuspIgG-protein fusion (type 1)CD73↓Yes
dapirolizumabFabCD40L
daratumumabIgGCD38
datopotamabIgGTROP-2
davoceticeptFc fusion protein (type 1)CD28/PD-L1/CTLA-4↓Yes
daxdilimabIgGILT7↑
dectrekumabIgGIL-13
demcizumabIgGDLL4Yes
demupitamabIgGEGFR
denintuzumabIgGCD19
denosumabIgGRANKL
depatuxizumabIgGEGFR
depemokimabIgGIL-5↑
derlotuximabIgGDNA-associated antigens↑
detumomabUnconfirmedB-lymphoma cell
dezamizumabIgGSerum amyloid P component
dilpacimabFv-IgGDLL4↓
dinutuximabIgGGD2
diridavumabIgGInfluenza A hemagglutininYes
disitamabIgGHER2
divozilimabIgGCD20
docaravimabIgGRabies virus
domagrozumabIgGMyostatin↓
domvanalimabIgGTIGIT↓Yes
donanemabIgGAmyloid betaYes
dorlimomabUnconfirmedricin
dostarlimabIgGPD-1Yes
dovanvetmabIgGIL-31 (feline)↓
dresbuxelimabIgGCD73↓
drozitumabIgGDR5Yes
dulaglutideFc fusion protein (type 1)GLP-1R↓Yes
duligotuzumabIgGHER3
dupilumabIgGIL-4RYesYes
durvalumabIgGPD-L1↓
dusigitumabIgGIGF1/IGF2
duvortuxizumabDiabody-Fc (type 2)CD19↓YesYes
ebdarokimabIgGIL-12 beta
eblasakimabIgGIL-13R alpha1Yes
ebronucimabIgGPCSK9
ecleralimabFabThymic stromal lymphopoietin
ecromeximabIgGGD3
eculizumabIgGC5
edobacomabUnconfirmedEndotoxin
edrecolomabUnconfirmedEpCAM
efalizumabIgGCD11a
efanesoctocogFc fusion protein (type 7)HemophiliaYes
efaprinerminFc fusion protein (type 1)GITRYes
efavaleukinFc fusion protein (type 6)IL-2R↓Yes
efbemalenograstimFc fusion protein (type 1)CD114↓
efdamrofuspFc fusion protein (type 3)VEGF
efepoetinFc fusion protein (type 1)EpoR
efgartigimodFc domainFcRnYes
efgivanerminFc fusion protein (type 6)GITR
efineptakinFc fusion protein (type 1)IL-7R
efinopegdutideProtein conjugated FcGLP-1R
efizonerimodFc fusion protein (type 6)TNFR
eflapegrastimProtein conjugated FcGCSFR
eflenograstimFc fusion protein (type 1)GCSFR
eflepedocokinFc fusion protein (type 1)IL-22R↓
eflimrufuspFc fusion protein (type 1)VEGF
efmarodocokinFc fusion protein (type 1)IL-22R↓
efmitermantFc fusion protein (type 1)Myostatin
efmoroctocogFc fusion protein (type 5)HemophiliaYes
efocipegtrutideProtein conjugated Fcglucagon/GLP1/GIP
efpeglenatideSmall molecule conjugated FcGLP-1R
efpegsomatropinProtein conjugated FcHGHR
efprezimodFc fusion protein (type 1)unknown
efrilacedaseFc fusion protein (type 1)Angiotensin
efruxiferminFc fusion protein (type 6)FGFR
eftansomatropinFc fusion protein (type 1)HGHR
eftilagimodFc fusion protein (type 1)HLA-DR
eftozanerminFc fusion protein (type 1)DR4/DR5↓
eftrenonacogFc fusion protein (type 5)HemophiliaYes
efungumabscFvHSP90
efzofitimodFc fusion protein (type 6)Neuropilin-2
eldelumabIgGCXCL10
elezanumabIgGRepulsive Guidance Molecule A↓↑
elgemtumabIgGHER3
elipovimabIgGHIV gp120↑↑
elotuzumabIgGSLAMF7
elranatamabBispecific IgG (type 6)BCMA↓Yes
elsilimomabUnconfirmedIL-6
eluvixtamabTandem scFvCD33
emactuzumabIgGCD115
emapalumabIgGInterferon gamma
emerfetamabTandem scFv-scFcCD33↓Yes
emfizatamabIgG-scFv (type 2)CD19↓Yes
emibetuzumabIgGHGFR↓YesYes
emicizumabBispecific IgG (type 2)Factor IxaYesYesYes
emirodatamabTandem scFv-scFcFLT3↓Yes
enapotamabIgGAXLYes
enavatuzumabIgGTWEAK-R
encelimabIgGLAG-3Yes
enfortumabIgGNectin-4
enibarcimabIgGAdrenomedulin
enlimomabUnconfirmedCD54
enoblituzumabIgGB7-H3↑
enokizumabIgGIL-9
enoticumabIgGDLL4Yes
ensituximabIgGMUC5ACYes
ensomafuspIgG-protein fusion (type 3)CD19↓Yes
enuzovimabIgGSARS-CoV-2↑Yes
envafolimabdAb-FcPD-L1
epcoritamabBispecific IgG (type 6)CD20↓YesYes
epitumomabUnconfirmedMUC1
epratuzumabUnconfirmedCD22
eptinezumabIgGCGRP↓Yes
eramkafuspIgG-protein fusion (type 1)CD20
erenumabIgGCGRPR
erfonrilimabTandem dAb-FcPD-L1
erlizumabF(ab')2CD18
ertumaxomabUnconfirmedHER2
etanerceptUnconfirmedTNF alpha
etaracizumabIgGIntegrin alpha5/beta3
etesevimabIgGSARS-CoV-2↓
etevritamabTandem scFvEGFR
etigilimabIgGTIGITYes
etokimabIgGIL-33
etrolizumabIgGIntegrin alpha4/beta7Yes
evinacumabIgGAngiopoietin-like 3Yes
evolocumabIgGPCSK9
evorpaceptFc fusion protein (type 1)CD47↓Yes
exbivirumabIgGHepatitis B virus
exidavnemabIgGSynuclein alphaYesYes
ezabenlimabIgGPD-1YesYes
fanolesomabUnconfirmedCD15
faralimomabUnconfirmedInterferon alpha
faricimabBispecific IgG (type 5)VEGF↓↓YesYes
farletuzumabIgGFOLR1
fasinumabIgGNGFYes
favezelimabIgGLAG-3Yes
fazpilodemabBispecific IgG (type 1)FGFR1↓Yes
feladilimabIgGCD278↓Yes
felvizumabUnconfirmedRespiratory syncytial virus
felzartamabIgGCD38
fezakinumabIgGIL-22Yes
fianlimabIgGLAG-3↓Yes
ficlatuzumabIgGHGF
fidasimtamabBispecific IgG (type 1)PD-1Yes
figitumumabIgGIGF1RYes
finotonlimabIgGPD-1Yes
firivumabIgGInfluenza A hemagglutinin
fiztasovimabIgGCMV
flanvotumabIgGGP75
fletikumabIgGIL-20Yes
flotetuzumabDiabodyCD123
fontolizumabIgGInterferon gamma
foralumabIgGCD3↓
foravirumabIgGRabies virusYes
fremanezumabIgGCGRP↓
fresolimumabIgGTGF beta
frexalimabIgGCD40L↑
frovocimabIgGPCSK9↓YesYes
frunevetmabIgGNGF (feline)
fulranumabIgGNGF
futuximabIgGEGFRYes
galcanezumabIgGCGRP↓YesYes
galegenimabFabHtrA1
galiximabIgGCD80↑
gancotamabscFvHER2
ganitumabIgGIGF1R
gantenerumabIgGAmyloid beta
garadacimabIgGFactor XIIaYes
garetosmabIgGActivin AYes
garivulimabIgGPD-L1↓
gatipotuzumabIgGMUC1
gatralimabIgGCD52
gavilimomabUnconfirmedCD147
gedivumabIgGInfluenza A hemagglutinin
gefurulimabTandem dAb (type 2)C5
gemtuzumabIgGCD33Yes
geptanolimabIgGPD-1YesYes
gevokizumabIgGIL-1 betaYes
giloralimabIgGCD40↓
gilvetmabIgGPDCD1 (canine)
gimsilumabIgGGM-CSF↑
ginisortamabIgGGREM1Yes
girentuximabIgGCarbonic anhydrase IX
glembatumumabIgGGPNMB
glenzocimabFabGP6
glofitamabFab-IgG (type 1)CD20↓YesYes
goflikiceptFc fusion protein (type 4)IL-1BYes
golimumabIgGTNF alpha
golocdacimabIgGLOX-1↓
gontivimabTriple dAb (type 1)Respiratory syncytial virus
gosuranemabIgGTauYesYes
gremubamabIgG-scFv (type 4)Pseudomonas aeruginosa
gresonitamabTandem scFv-scFcClaudin 18.2↓Yes
grisnilimabIgGCD7
gumokimabIgGIL-17
guselkumabIgGIL-23Yes
ianalumabIgGBAFF↑
ibalizumabIgGCD4
ibritumomabUnconfirmedCD20
icrucumabIgGVEGF-R1
idactamabIgGASCT2Yes
idarucizumabFabDabigatran
ieramilimabIgGLAG-3YesYes
ifabotuzumabIgGEPHA3↑
ifinatamabIgGB7-H3
igovomabUnconfirmedCA125
iladatuzumabIgGCD79b
imalumabIgGMIF
imaprelimabIgGMCAM↓
imciromabUnconfirmedCardiac myosin
imdevimabIgGSARS-CoV-2
imgatuzumabIgGEGFRYes
imsidolimabIgGIL-36RYes
imvotamabIgM with J chain fusionCD20
inbakiceptFc fusion protein (type 1)IL-15
inclacumabIgGCD62↓Yes
indatuximabIgGCD138
indusatumabIgGGuanylyl cyclase C
inebilizumabIgGCD19↑
inezetamabIgG-scFv (type 1)Mesothelin↓YesYes
infliximabUnconfirmedTNF alpha
inolimomabUnconfirmedCD25
inotuzumabIgGCD22Yes
intetumumabIgGIntegrin alpha5/beta3
ipafriceptFc fusion protein (type 1)WNT ligand
iparomlimabIgGPD-1Yes
ipilimumabIgGCTLA-4
iratumumabIgGCD30
isatuximabIgGCD38
iscalimabIgGCD40↓
isecarosmabTandem dAb (type 2)ADAMTS-5
ispectamabIgGBCMAYes
istiratumabIgG-scFv (type 1)IGF1RYes
itepekimabIgGIL-33Yes
itolizumabIgGCD6
ivicentamabBispecific IgG (type 6)CD37↑YesYes
ivonescimabIgG-scFv (type 1)PD-1↓
ivuxolimabIgGOX40
ixekizumabIgGIL-17AYesYes
izalontamabIgG-scFv (type 1)EGFRYes
izenivetmabIgGNGF (canine)↓
izuralimabHeterodimeric Fab/scFv-FcPD-1↓↑Yes
keliximabUnconfirmedCD4
labetuzumabIgGCEACAM5
lacnotuzumabIgGM-CSF
lacutamabIgGKIR3DL2↑
ladiratuzumabIgGLIV-1
lampalizumabFabFactor D
lanadelumabIgGPlasma kallikreinYes
landogrozumabIgGMyostatinYesYes
laprituximabIgGEGFRYes
larcaviximabIgGEbola virus
latikafuspIgG-protein fusion (type 2)PD-1↓YesYesYes
latozinemabIgGSortilin↓
lebrikizumabIgGIL-13Yes
lecanemabIgGAmyloid beta
lemalesomabIgGNCA-90
lemzoparlimabIgGCD47Yes
lenerceptFc fusion protein (type 1)TNF alpha
lenvervimabIgGHepatitis B virus
lenzilumabIgGGM-CSF
lepunafuspFab-protein fusion (type 1)Transferrin receptor
lerdelimumabIgGTGF beta
leronlimabIgGCCR5
lesabelimabIgGPD-L1
lesofavumabIgGInfluenza B hemagglutinin
letaplimabIgGCD47↓YesYes
letolizumabdAb-FcCD40L
levilimabIgGIL-6R↓↑
lexatumumabIgGTRAIL-R2
libivirumabIgGHepatitis B virus
licaminlimabscFvTNF alpha
lifastuzumabIgGNaPi2b
ligelizumabIgGIgE
ligufalimabIgGCD47Yes
lilotomabIgGCD37
lintuzumabIgGCD33
linvoseltamabBispecific IgG (type 3)BCMA↓YesYes
lirentelimabIgGSiglec-8↑
lirilumabIgGKIRD2Yes
litifilimabIgGCLEC4CYes
livmoniplimabIgGLRRC32YesYes
lodapolimabIgGPD-L1↓
lodelcizumabIgGPCSK9↓
lokivetmabIgGIL-31
lomtegovimabIgGSARS-CoV-2Yes
loncastuximabIgGCD19Yes
lonigutamabIgGIGF1RYes
lorigerlimabDiabody-Fc (type 1)PD-1↑Yes
lorukafuspIgG-protein fusion (type 1)GD2
lorvotuzumabIgGCD56
losatuxizumabIgGEGFR
lucatumumabIgGCD40Yes
lulizumabdAbCD28
lumiliximabUnconfirmedCD23
lumretuzumabIgGHER3Yes
lupartumabIgGLYPD3Yes
luspaterceptFc fusion protein (type 1)ActRIIA ligands
lusvertikimabIgGIL-7RYes
lutikizumabFv-IgGIL-1 alpha↓
luveltamabIgGFOLR1Yes
maftivimabIgGEbola virus
magrolimabIgGCD47Yes
manelimabIgGPD-L1↓
manfidokimabIgGIL-4RYes
mapatumumabUnconfirmedTRAIL-R1
margetuximabIgGHER2↑
marstacimabIgGTissue factor pathway inhibitor↓Yes
masavibartIgGSARS-CoV-2↓↑
maslimomabUnconfirmedTCR
matuzumabUnconfirmedEGFR
mavrilimumabIgGCD116
mazorelvimabIgGRabies virus
mecbotamabIgGAXLYes
melredableukinIgG-protein fusion (type 1)IL-2R↓Yes
melrilimabIgGIL-33R↓
mepolizumabIgGIL-5
metelimumabIgGTGF beta
mezagitamabIgGCD38
mibavademabIgGLEPRYes
milatuzumabIgGCD74
minretumomabUnconfirmedTag-72
mipasetamabIgGAXLYes
miptenalimabIgGLAG-3YesYes
mirikizumabIgGIL-23↓YesYes
miromavimabIgGRabies virus
mirvetuximabIgGFOLR1Yes
mirzotamabIgGB7-H3↓
mitazalimabIgGCD40
mitumomabUnconfirmedGD3
modakafuspIgG-protein fusion (type 1)CD38Yes
modotuximabIgGEGFRYes
mogamulizumabIgGCCR4
monalizumabIgGCD159aYes
morolimumabUnconfirmedRhesus D
mosunetuzumabBispecific IgG (type 1)CD20↓Yes
motavizumabIgGRespiratory syncytial virus
moxetumomabFv-protein fusionCD22
mupadolimabIgGCD73↓
murlentamabIgGMullerian inhibiting substance type II
muromonabUnconfirmedCD3
nacolomabUnconfirmedColorectal tumor antigen
nadecnemabIgGGFRa3Yes
nadunolimabIgGIL-1R accessory proteinYes
namilumabIgGGM-CSF
naptumomabFab-protein fusion (type 1)TPBG
naratuximabIgGCD37Yes
narnatumabIgGRON8
narsoplimabIgGMASP-2Yes
natalizumabIgGIntegrin alpha4
navicixizumabBispecific IgG (type 2)DLL4Yes
navivumabIgGInfluenza A hemagglutinin
naxitamabIgGGD2
nebacumabUnconfirmedEndotoxin
necitumumabIgGEGFR
nemolizumabIgGIL-31R alphaYes
nepuvibartIgGSARS-CoV-2↓↑
nerelimomabUnconfirmedTNF alpha
nesvacumabIgGAng-2
netakimabIgGIL-17↑
nimacimabIgGCannabinoid 1 receptorYes
nimotuzumabIgGEGFR
nipocalimabIgGFcRn↓YesYes
nirsevimabIgGRespiratory syncytial virus↑
nivatrotamabIgG-scFv (type 3)GD2↓
nivolumabIgGPD-1Yes
nofazinlimabIgGPD-1Yes
nofetumomabUnconfirmedGP40
nurulimabIgGCTLA-4Yes
obexelimabIgGCD19↑
obiltoxaximabIgGBacillus anthrax
obinutuzumabIgGCD20
obrindatamabDiabody-Fc (type 2)B7-H3↓YesYes
ocaratuzumabIgGCD20↑Yes
ociperlimabIgGTIGIT
ocrelizumabIgGCD20
odesivimabIgGEbola virus
odronextamabBispecific IgG (type 3)CD20↓YesYes
odulimomabUnconfirmedCD11a
ofatumumabIgGCD20
ogalvibartIgGSARS-CoV-2↑Yes
olamkiceptFc fusion protein (type 1)IL-6↓
olaratumabIgGPDGF alpha
oleclumabIgGCD73↓
olendalizumabIgGC5
olinvacimabIgGVEGF-R2
olokizumabIgGIL-6Yes
omalizumabIgGIgE
omburtamabIgGCD276
omodenbamabIgGStaphylococcus aureus
onartuzumabHeterodimeric Fab-FcHGFRYes
onfekafuspscFv-protein fusionFibronectin
ongericimabIgGPCSK9Yes
ontamalimabIgGMADCAM
ontorpaceptFc fusion protein (type 1)CD47
ontuxizumabIgGEndosialinYes
onvatilimabIgGVISTA
opicinumabIgGLINGO↓Yes
opinerceptFc fusion protein (type 1)TNF alpha
oportuzumabscFv-protein fusionEpCAM
opucolimabIgGPD-L1↓
ordesekimabIgGIL-15
oregovomabUnconfirmedCA125
orilanolimabIgGFcRnYesYes
ormutivimabIgGRabies virus
orticumabIgGOxidized LDL
osemitamabIgGClaudin 18.2
osocimabIgGFactor XIaYes
otelixizumabIgGCD3↓
otilimabIgGGM-CSF
otlertuzumabscFv-FcCD37
oxelumabIgGOX40LYes
ozanezumabIgGNOGO-A↓
ozoralizumabTriple dAb (type 2)TNF alpha
ozuriftamabIgGROR2Yes
pabinafuspIgG-protein fusion (type 1)Transferrin receptor
pacanalotamabTandem scFvBCMA
pacmilimabProtease activated IgGPD-L1YesYes
pagibaximabUnconfirmedLipoteichoic acid
palivizumabUnconfirmedRespiratory syncytial virus
pamrevlumabIgGCTGFYes
panitumumabIgGEGFR
panobacumabIgMPseudomonas aeruginosa
paridiprubartIgGTLR4↑
parsatuzumabIgGEGFL7
pascolizumabIgGIL-4
pasotuxizumabTandem scFvPSMA
pateclizumabIgGLymphotoxin alphaYes
patritumabIgGHER3
pavurutamabTandem scFv-scFcBCMA↓Yes
pelgifatamabIgGPSMA
pembrolizumabIgGPD-1Yes
penpulimabIgGPD-1↓
pepinemabIgGSEMA4DYes
perakizumabIgGIL-17A↓
peresolimabIgGPD-1
pertuzumabIgGHER2Yes
petosemtamabBispecific IgG (type 2)EGFRYesYes
pexelizumabscFvC5
pidilizumabIgGDLL1
pimivalimabIgGPD-1Yes
pimurutamabIgGEGFR
pinatuzumabIgGCD22
pintumomabUnconfirmedAdenocarcinoma antigen
pivekimabIgGIL-3RYesYes
placulumabdAb-FcTNF alpha
plamotamabHeterodimeric Fab/scFv-FcCD20↓Yes
plonmarlimabIgGGM-CSF
plozalizumabIgGCCR2↓
plutavimabIgGSARS-CoV-2↓
polatuzumabIgGCD79b
ponezumabIgGAmyloid beta↓
ponsegromabIgGGrowth Differentiation Factor 15↓Yes
porgaviximabIgGEbola virus
posdinemabIgGTau
pozelimabIgGC5Yes
praluzatamabProtease activated IgGCD166Yes
prasinezumabIgGSynuclein alpha
prezalumabIgGCD28
priliximabUnconfirmedCD4
pritoxaximabIgGShiga-like toxin
pritumumabIgGVimentin
prolgolimabIgGPD-1↓
pucotenlimabIgGPD-1↑Yes
pulocimabIgGVEGF-R2
quavonlimabIgGCTLA-4
quetmolimabIgGFractalkine↓
quilizumabIgGIgE
quisovalimabIgGLIGHT↓YesYes
racotumomabIgGGM3
radretumabscFv-protein fusionFibronectin
rafivirumabIgGRabies virusYes
ragifilimabIgGGITRYes
ralpancizumabIgGPCSK9↓
ramaterceptFc fusion protein (type 1)ActRIIA ligands↓
ramucirumabIgGVEGF-R2Yes
ranevetmabIgGNGF (canine)
ranibizumabFabVEGF
ravagalimabIgGCD40↓↑
ravulizumabIgGC5
raxibacumabUnconfirmedBacillus anthrax
recaticimabIgGPCSK9↑
refanezumabIgGMyelin associated glycoprotein↓
regavirumabUnconfirmedHerpes virus
regdanvimabIgGSARS-CoV-2Yes
relatlimabIgGLAG-3Yes
relfovetmabIgGNGF (feline)
remtolumabFv-IgGTNF alpha
reozalimabBispecific IgG (type 4)PD-1↓Yes
reslizumabUnconfirmedIL-5
retifanlimabIgGPD-1YesYes
retlirafuspIgG-protein fusion (type 1)PD-L1↓YesYes
revdofilimabIgGOX40
rilonaceptFc fusion protein (type 2)IL-1 alpha
rilotumumabIgGHGF
rimteravimabdAb-FcSARS-CoV-2↓Yes
rinucumabIgGPDGF betaYes
ripertamabIgGCD20
risankizumabIgGIL-23↓Yes
rituximabIgGCD20
rivabazumabFabPseudomonas aeruginosaYes
robatumumabIgGIGF1R
rocatinlimabIgGOX40
roledumabIgGRhesus D
rolinsatamabIgGProlactin receptorYes
romilkimabFv-IgGIL-4↓YesYes
romlusevimabIgGSARS-CoV-2↑
romosozumabIgGSclerostin
rontalizumabIgGInterferon alpha
rosmantuzumabIgGRSPO3
rosnilimabIgGPD-1
rosopatamabIgGPSMA
rovalpituzumabIgGDLL3Yes
rovelizumabIgGCD18
rozanolixizumabIgGFcRnYes
rozibafuspIgG-protein fusion (type 1)BAFF
rulonilimabIgGPD-1↓↑
runimotamabBispecific IgG (type 1)HER2↓Yes
ruplizumabIgGCD40LYes
sabatolimabIgGTIM-3YesYes
sacituzumabIgGTROP-2
samalizumabIgGCD200
samrotamabIgGLRRC15
sarilumabIgGIL-6R
sasanlimabIgGPD-1Yes
satralizumabIgGIL-6RYes
satumomabIgGTag-72Yes
secukinumabIgGIL-17A
selicrelumabIgGCD40
semorinemabIgGTau↑Yes
semzuvolimabIgGCD4↓
serclutamabIgGEGFRYes
seribantumabIgGHER3
serplulimabIgGPD-1Yes
setoxaximabIgGShiga-like toxin
setrusumabIgGSclerostin
sevirumabUnconfirmedCMV
sibeprenlimabIgGAPRIL
sibrotuzumabUnconfirmedFAP
sifalimumabIgGInterferon alpha
siltuximabIgGIL-6
simlukafuspIgG-protein fusion (type 2)FAP↓YesYes
simridarlimabHeterodimeric Fab/scFv-FcPD-L1↓YesYes
simtuzumabIgGLOXL2Yes
sintilimabIgGPD-1Yes
siplizumabUnconfirmedCD2
sirexatamabIgGDKK1↓YesYes
sirtratumabIgGSLITRK6
sirukumabIgGIL-6
socazolimabIgGPD-L1
sofituzumabIgGMUC16
solanezumabIgGAmyloid beta
solitomabTandem scFvEpCAM
sonelokimabTriple dAb (type 3)IL-17A
sontuzumabUnconfirmedMUC1
sotaterceptFc fusion protein (type 1)ActRIIA ligands↓
sotevtamabIgGClusterin
sotigalimabIgGCD40↑
sotrovimabIgGSARS-CoV-2↑
soziniberceptFc fusion protein (type 1)VEGF-R3
spartalizumabIgGPD-1YesYes
spesolimabIgGIL-36R↓
stamulumabIgGMyostatin
suciraslimabIgGCD22
sudubrilimabIgGPD-1↓Yes
sugemalimabIgGPD-L1Yes
sulesomabUnconfirmedNCA-90
suptavumabIgGRespiratory syncytial virus
surzebiclimabIgGTIM-3↓
sutimlimabIgGC1s↓Yes
suvizumabIgGHIV gp120
suvratoxumabIgGStaphylococcus aureus↑
tabalumabIgGBLysYesYes
tabituximabIgGFrizzled homolog 10
tacatuzumabIgGAlpha fetoprotein
tadocizumabFabIntegrin alpha2b/beta3
tafasitamabIgGCD19↑
tafolecimabIgGPCSK9Yes
tagitanlimabIgGPD-L1↓
talacotuzumabIgGIL-3R↑
talizumabIgGIgE
talquetamabBispecific IgG (type 6)GPCR5D↓YesYes
tamgiblimabIgGTIGIT↓YesYes
tamrintamabIgGDPEP3YesYes
tamtuvetmabIgGCD52
tanezumabIgGNGF↓
taplitumomabUnconfirmedCD19
tarcocimabIgGVEGF↓Yes
tarextumabIgGNotch-2/Notch-3
tarlatamabTandem scFv-scFcDLL3↓YesYes
tavolimabIgGOX40
tebentafuspscFv-TCR fusiongp100
tebotelimabDiabody-Fc (type 1)PD-1 ↑Yes
tecaginlimabBispecific IgG (type 6)CD40↓YesYes
teclistamabBispecific IgG (type 6)BCMA↓YesYesYes
tefibazumabUnconfirmedStaphylococcus aureus
telazorlimabIgGOX40
telimomabUnconfirmedCD5
telisotuzumabIgGHGFRYesYes
telitaciceptFc fusion protein (type 1)BLyS/APRIL↓
temelimabIgGHERVYes
tenatumomabIgGTenascin-C
teneliximabIgGCD40
teplizumabIgGCD3↓
tepoditamabBispecific IgG (type 2)CLEC12A↓YesYes
teprotumumabIgGIGF1R
teropavimabIgGHIV gp120↑Yes
tesidolumabIgGC5↓
tesnatilimabIgGCD314Yes
tezepelumabIgGThymic stromal lymphopoietin
tibulizumabIgG-scFv (type 1)BAFFYesYesYes
tidutamabHeterodimeric Fab/scFv-FcSSTR2↓Yes
tifcemalimabIgGBTLAYes
tigatuzumabIgGTRAIL-R2
tilavonemabIgGTauYes
tildrakizumabIgGIL-23
tilogotamabIgGDR5↑Yes
tilvestamabIgGAXL
timigutuzumabIgGHER2
timolumabIgGVascular adhesion protein-1↓Yes
tinurilimabIgGCEACAM6Yes
tiragolumabIgGTIGIT
tirnovetmabIgGIL-31 (canine)
tislelizumabIgGPD-1↓Yes
tisotumabIgGThromboplastin
tixagevimabIgGSARS-CoV-2↓↑
tocilizumabIgGIL-6RYes
tomaralimabIgGTLR2Yes
tomuzotuximabIgGEGFR
toralizumabUnconfirmedCD40L
toripalimabIgGPD-1Yes
torudokimabIgGIL-33↓YesYes
tosatoxumabIgGStaphylococcus aureus
tositumomabUnconfirmedCD20
tovetumabIgGPDGF alpha
tozorakimabIgGIL-33
tralokinumabIgGIL-13
trastuzumabIgGHER2Yes
trebananibFc fusion protein (type 6)Ang-1/Ang-2
tregalizumabIgGCD4
tremelimumabIgGCTLA-4
trevogrumabIgGMyostatinYes
trinbelimabIgGRhesus DYes
trontinemabFab-IgG (type 3)Amyloid betaYesYes
tucotuzumabIgG-protein fusion (type 1)EpCAM
tulinerceptFc fusion protein (type 1)TNF alpha
tusamitamabIgGCEACAM5Yes
tuvirumabUnconfirmedHepatitis B virus
tuvonralimabIgGCTLA-4Yes
ubamatamabBispecific IgG (type 3)MUC16↓YesYes
ublituximabIgGCD20
ulenistamabIgGPAUFYes
uliledlimabIgGCD73↓
ulocuplumabIgGCXCR4YesYes
unasnemabIgGRepulsive Guidance Molecule A
upanovimabIgGSARS-CoV-2↓
upifitamabIgGNaPi2bYes
urabrelimabIgGCD47Yes
urelumabIgG4-1BBYes
urtoxazumabIgGShiga-like toxin
ustekinumabIgGIL-12/IL-23
utomilumabIgG4-1BB
vadastuximabIgGCD33Yes
valanafuspIgG-protein fusion (type 1)Insulin receptorYes
vandortuzumabIgGSTEAP1
vantictumabIgGFrizzled homolog 7Yes
vanucizumabBispecific IgG (type 5)Ang-2Yes
vapaliximabUnconfirmedVascular adhesion protein-1
varisacumabIgGVEGF
varlilumabIgGCD27
vatelizumabIgGIntegrin alpha2/beta1
vedolizumabIgGIntegrin alpha4/beta7↓
veltuzumabIgGCD20
vepalimomabUnconfirmedVascular adhesion protein-1
vepsitamabTandem scFv-scFcMUC17↓Yes
vesencumabIgGNeuropilin 1
vibecotamabHeterodimeric Fab/scFv-FcCD123↓Yes
vibostolimabIgGTIGIT
vilobelimabIgGC5
visilizumabIgGCD3↓Yes
visugromabIgGGDF15YesYes
vixarelimabIgGOncostatin M receptor↓YesYes
vixtimotamabTandem scFvCD33
vobarilizumabTandem dAb (type 2)IL-6R
vobramitamabIgGB7-H3
vofatamabIgGFGFR3
volagidemabIgGGCGR
volociximabIgGIntegrin alpha5/beta1
vonlerolizumabIgGOX40
vopratelimabIgGCD278
vorsetuzumabIgGCD70
votumumabUnconfirmedCTAA16.88
voxalatamabBispecific IgG (type 6)PSMA↓YesYes
vudalimabHeterodimeric Fab/scFv-FcPD-1↓↑Yes
vulinacimabIgGVEGF-R2
vunakizumabIgGIL-17A
xeligekimabIgGIL-17AYes
xentuzumabIgGIGF1/IGF2Yes
zagotenemabIgGTau↓YesYes
zalifrelimabIgGCTLA-4
zalutumumabIgGEGFR
zamerovimabIgGRabies virus
zampilimabIgGTransglutaminase 2Yes
zanidatamabHeterodimeric Fab/scFv-FcHER2YesYes
zanolimumabUnconfirmedCD4
zansecimabIgGAng-2↓YesYes
zelminemabIgGPAC1 receptor type 1↓
zeluvalimabIgGPD-1↓Yes
zenocutuzumabBispecific IgG (type 2)HER2YesYes
zilovertamabIgGROR1
ziltivekimabIgGIL-6↑
zimberelimabIgGPD-1Yes
zinlirvimabIgGHIV gp120↑Yes
ziralimumabUnconfirmedCD147
zolbetuximabIgGClaudin 18.2
zolimomabUnconfirmedCD5
zuberitamabIgGCD20

Licensing - STR technology is available to license

We are not involved in the research and development of our own biological therapeutics. Instead, it is our strong belief that the STR technology can be of real benefit to a large proportion of antibody and Fc fusion proteins currently being developed. We are therefore actively seeking to license our technology widely on affordable terms with non-exclusive research and commercial licenses available. Payments are based on a few simple success-based milestones with no royalties.