mAbsolve has now had patents for the STR silencing mutations granted in the United States (US12037380B2), Canada (CA3179582), United Kingdom (GB2595299B), Australia (AU2021277578B2) and Japan (JP7434609B2). We continue to push forward with our applications in other territories and expect these to be awarded in due course.
Antibodies
mAbsolve will be exhibiting at the Festival of Biologics in Basel on the 10-12th of October. We will be located in the startup zone will also have a poster with a more detailed description of our technology in the poster area. Please do come along and chat with us to understand how we can help … Read more
Our CEO, Geoff Hale, has been confirmed as a keynote speaker at Antibody Engineering and Therapeutics 2023 in Amsterdam. Geoff will be talking about the diversity of antibody formats and modiciations utilised in the clinic and in particular focussing on Fc silencing and the work mAbsolve has done to compare it’s STR silencing mutations with … Read more
Dr. Neil Bodie and colleagues at Paradigm Immunotherapeutics along with collaborators at Kyoto University and Michigan State University have reported on the design of an ultra-high affinity ACE2 variant that has been coupled to an Fc domain incorporating mAbsolve’s STR mutations for silencing and the YTE mutations for half-life extension. It is hoped that this … Read more
On Thursday 22nd September, our CEO, Geoff Hale, will be presenting some of our recent work on the analysis of Fc sequences from antibodies and Fc fusion proteins and the range of variants used for Fc silencing. Abstract: Over the last 40 years, antibodies and antibody-related biologics have probably been the greatest growth area for … Read more
Today our CEO and CSO, Geoff Hale and Ian Wilkinson, have had a new article published in mAbs. The work described in the article started as an internal effort to better understand the number of silenced antibodies in clinical development and the mutations they used. However, the goal of this work broadened out very quickly … Read more